Association between virological response and decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in HCV genotype 1: another story

We read with great interest the article in Hepatology by Sievert et al.,1 which retrospectively evaluated the CHARIOT study of 871 treatment-naive patients who were infected with hepatitis C virus (HCV) genotype 1 (HCV-1) to determine whether hemoglobin decline is associated with sustained virological response (SVR) achieved through pegylated interferon (PegIFN) and ribavirin treatment. With 16% of patients developing anemia (serum hemoglobin...