The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency
Abstract
IgA deficiency (IgAD) and common variable immunodeficiency (CVID) often co-occur in families, associating with chronic inflammatory diseases such as celiac disease (CD). ICOS (inducible co-stimulator) and CTLA4 (cytotoxic T-lymphocyte-associated protein-4) may be important in both disorders, as ICOS is necessary for Ig class-switching and CTLA4 negatively regulates T-cell activation. Linkage and association of CD with CTLA4-ICOS is well...
Paper Details
Title
The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency
Published Date
Nov 20, 2008
Journal
Volume
10
Issue
2
Pages
151 - 161
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