Locus-specific editing of histone modifications at endogenous enhancers
Abstract
Mammalian gene regulation is dependent on tissue-specific enhancers that can act across large distances to influence transcriptional activity. Mapping experiments have identified hundreds of thousands of putative enhancers whose functionality is supported by cell type-specific chromatin signatures and striking enrichments for disease-associated sequence variants. However, these studies did not address the in vivo functions of the putative...
Paper Details
Title
Locus-specific editing of histone modifications at endogenous enhancers
Published Date
Dec 1, 2013
Journal
Volume
31
Issue
12
Pages
1133 - 1136
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Notes
History