The Adverse Effect of IFN Gamma on Stratum Corneum Structure and Function in Psoriasis and Atopic Dermatitis

There is a marked increase in cytokines, including interferon gamma, in cutaneous diseases such as atopic dermatitis and psoriasis. In this issue of the Journal, Tawada and colleagues demonstrate that the quantity of ultra long-chain ceramides in the stratum corneum, which play a key role in maintaining the permeability barrier, is reduced in atopic dermatitis and psoriasis. Further, they demonstrate that interferon gamma decreases the...