Atypical Hemolytic Uremic Syndrome

Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening disease caused by uncontrolled activation of the alternative pathway of complement. Clinically, patients usually have the classic triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI), although almost any organ in the body is susceptible to injury. An increasing number of genes encoding complement regulatory proteins have been identified...