Investigation of Water Mobility and Diffusivity in Hydrating Micronized Low-substituted Hydroxypropyl Cellulose, Hydroxypropylmethyl Cellulose, and Hydroxypropyl Cellulose Matrix Tablets by Magnetic Resonance Imaging (MRI).

The water mobility and diffusivity in the gel-layer of hydrating low-substituted hydroxypropyl cellulose (LH41) tablets with or without a drug were investigated by magnetic resonance imaging (MRI) and compared with those properties in the gel-layer of hydroxypropylmethyl cellulose (HPMC) and hydroxypropyl cellulose (HPC) tablets. For this purpose, a localized image-analysis method was newly developed, and the spin-spin relaxation time (T(2)) and...