Match!

Lipids and Lipoproteins and Risk of Different Vascular Events in the MRC/BHF Heart Protection Study

Published on May 22, 2012in Circulation23.05
· DOI :10.1161/CIRCULATIONAHA.111.073684
S Parish55
Estimated H-index: 55
(Clinical Trial Service Unit),
Alison Offer9
Estimated H-index: 9
(Clinical Trial Service Unit)
+ 5 AuthorsRory Collins131
Estimated H-index: 131
(Clinical Trial Service Unit)
Abstract
Background—Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein particle concentrations may be stronger determinants of risk. Methods and Results—Associations between vascular events and baseline concentrations of cholesterol fractions, apolipoproteins B and A1, and lipoprotein particles assessed by nuclear magnetic resonance were considered in the Heart Protection Study randomized trial of simvastatin versus placebo (>5000 vascular events during 5.3 years of follow-up among 20 000 participants). Major occlusive coronary events were equally strongly associated with the cholesterol- and particle-based total LDL measures; adjusted hazard ratios per 1-SD-higher level were 1.25 (95% confidence interval [CI], 1.16–1.34) for LDL cholesterol, 1.22 (95% CI, 1.14–1.32) for non–HDL cholesterol, 1.23 (95% CI, 1.15–1.33) for apolipoprotein B, and 1.25 (95% CI, 1.16–1.35) for LDL particle number. Given the total LDL ...
  • References (39)
  • Citations (130)
References39
Newest
#1Benoit J. Arsenault (UvA: University of Amsterdam)H-Index: 34
#2S. Matthijs Boekholdt (UvA: University of Amsterdam)H-Index: 56
Last.John J. P. Kastelein (UvA: University of Amsterdam)H-Index: 119
view all 3 authors...
#1Robert S. Rosenson (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 59
#2H. Bryan Brewer (Memorial Hospital of South Bend)H-Index: 67
Last.Ernst J. Schaefer (Tufts University)H-Index: 117
view all 10 authors...
Cited By130
Newest
#1Young-Mee Koh (Daejeon University)
#2Soon-Woo Jang (Daejeon University)H-Index: 1
Last.Taek-Won Ahn (Daejeon University)H-Index: 3
view all 3 authors...
#1Xin Su (CSU: Central South University)H-Index: 2
#2Yi Kong (CSU: Central South University)H-Index: 1
Last.Daoquan Peng (CSU: Central South University)H-Index: 6
view all 3 authors...
#1Marc Allard-Ratick (Emory University)H-Index: 2
#2Bryan Kindya (Emory University)H-Index: 1
Last.Laurence Sperling (Emory University)H-Index: 30
view all 7 authors...
View next paperHigh-density lipoprotein cholesterol and particle concentrations, carotid atherosclerosis, and coronary events: MESA (Multi-Ethnic Study of Atherosclerosis)