Role of the glucosamine pathway in fat-induced insulin resistance.

Volume: 99, Issue: 9, Pages: 2173 - 2182
Published: May 1, 1997
Abstract
To examine whether the hexosamine biosynthetic pathway might play a role in fat-induced insulin resistance, we monitored the effects of prolonged elevations in FFA availability both on skeletal muscle levels of UDP-N-acetyl-hexosamines and on peripheral glucose disposal during 7-h euglycemic-hyperinsulinemic (approximately 500 microU/ml) clamp studies. When the insulin-induced decrease in the plasma FFA levels (to approximately 0.3 mM) was...
Paper Details
Title
Role of the glucosamine pathway in fat-induced insulin resistance.
Published Date
May 1, 1997
Volume
99
Issue
9
Pages
2173 - 2182
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