Changes in kidney function in patients with suppressed HIV RNA who substitute their protease inhibitor with atazanavir/ritonavir

Atazanavir (ATV) is a protease inhibitor licensed for the treatment of HIV infection, and one of the preferred agents for first-line therapy in the UK [1]. The use of ATV, however, has been associated with a number of kidney syndromes, including acute interstitial nephritis [2,3], chronic kidney disease (CKD) [4], rapid decline in estimated glomerular filtration rate (eGFR) [5], proximal kidney tubular dysfunction [6,7] and nephrolithiasis...