Preparation, characterization and properties in vitro and in vivo of a paclitaxel–albumin conjugate

Volume: 47, Issue: 3, Pages: 293 - 304
Published: Sep 8, 1997
Abstract
Paclitaxel (taxol) is in routine clinical use for treatment of a variety of cancers. Because of its low aqueous solubility, it requires Cremophor EL (polyethoxylated castor oil) and ethanol as a vehicle (Diluent 12). These agents cause severe allergic reactions upon intravenous administration. In this study paclitaxel was covalently attached to human serum albumin. The 2′-hydroxyl group of the drug was esterefied with succinic anhydride and then...
Paper Details
Title
Preparation, characterization and properties in vitro and in vivo of a paclitaxel–albumin conjugate
Published Date
Sep 8, 1997
Volume
47
Issue
3
Pages
293 - 304
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