Control of morphogenesis and actin localization by thePenicillium marneffei RAChomolog

Rac proteins control polarized growth in many organisms but the specific function of these proteins remains undefined. In this study, we describe the cloning and functional characterization of a RAC homolog, cflB, from the dimorphic fungus Penicillium marneffei. P. marneffei produces asexual spores on complex structures (conidiophores)and switches between hyphal and yeast growth. CflB colocalizes with actin at the tips of vegetative hyphal cells...