Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms

Recent estimates indicate that diabetes mellitus currently affects more than 10 % of the world’s population. Evidence from both the laboratory and large scale clinical trials has revealed that prolonged hyperglycemia induces chronic complications which persist and progress unimpeded even when glycemic control is pharmaceutically achieved via the phenomenon of metabolic memory. The epigenome is comprised of all chromatin modifications including...