Minocycline inhibits apoptotic cell death via attenuation of TNF‐α expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co‐cultures

We attempted to ascertain the neuroprotective effects and mechanisms of minocycline in inflammatory‐mediated neurotoxicity using primary neuron/glia co‐cultures treated with lipopolysaccharide (LPS). Neuronal cell death was induced by treatment with LPS for 48 h, and the cell damage was assessed using lactate dehydrogenase (LDH) assays and by counting microtubule‐associated protein‐2 (MAP‐2) positive cells. Through terminal transferase...