Cell Cycle-related Changes in the Voltage-gated Ca2+Currents in Cultured Newborn Rat Ventricular Myocytes

The expression of T-type Ca2+current (ICa,T) has been reported to change during postnatal heart development and myocardial hypertrophy, which are characterized respectively by the arrest of the cell cycle soon after birth and a switching on of DNA synthesis in the terminally differentiated cardiac myocytes. The hypothesis that there are cell cycle-related changes in cardiac Ca2+channel expression was tested by performing whole-cell voltage-clamp...