Regulatory T cell properties of thymic CD4+CD25+ cells in ducks

Thymic CD4+CD25+ cells from ducks were characterized for mammalian T regulatory cells’ suppressive and cytokine production properties. The cross reactivity of anti-chicken CD25 monoclonal antibody with duck CD25 was confirmed by evaluating Concanavalin-A-stimulated CD25 upregulation in splenocytes. CD4+CD25+ cells were detectable in the thymus, spleen, cecal tonsil, and lung (airsacs), but not in the bursa. Duck CD4+CD25+ cells had approximately...