Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux
Abstract
Accumulating evidence has revealed that autophagy may be beneficial for treatment of neurodegenerative diseases through removal of abnormal protein aggregates. However, the critical autophagic events during neurodegeneration remain to be elucidated. Here, we investigated whether prototypic autophagic events occur in the MN9D dopaminergic neuronal cell line upon exposure to N-methyl-4-phenylpyridinium (MPP+), a well-known dopaminergic neurotoxin....
Paper Details
Title
Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux
Published Date
Jan 1, 2011
Journal
Volume
7
Issue
1
Pages
51 - 60
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