LINE-1 Retrotransposition Activity in Human Genomes
Abstract
Highly active (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of hot L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 full-length L1s that are differentially present among individuals but are absent from the human genome reference sequence. The...
Paper Details
Title
LINE-1 Retrotransposition Activity in Human Genomes
Published Date
Jun 1, 2010
Journal
Volume
141
Issue
7
Pages
1159 - 1170
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