Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins

The inner root sheath (IRS) sustains and addresses the hair shaft outside the follicle. Ultrastructural analysis of immunolabeling for beta-catenin, plakophilin-1, desmoglein-4 and keratin-17 in human hairs has indicated that adherens junctions and desmosomes initially connect cells in mature IRS and the companion layer. Beta-catenin immunolabeling for adherens junctions is only seen in sparse regions of differentiating Huxley cells,...