Glutathione modifies the toxicity of triethyltin and trimethyltin in C6 glioma cells

It has been demonstrated that exposure to mercury or cadmium compounds causes alterations in the glutathione system in a model glial cell line, C6. Here we report that two organic tin compounds, triethyltin (TET) and trimethyltin (TMT), are also toxic to these cells with EC50 values for cell death of c. 0.02 μM and 0.8 μM respectively. Exposure for 24 h to either of these compounds at sub-toxic concentrations caused increases in the amount of...