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Individual differences in regional prefrontal gray matter morphometry and fractional anisotropy are associated with different constructs of executive function

Published on May 1, 2015in Brain Structure & Function3.62
· DOI :10.1007/s00429-014-0723-y
Harry R. Smolker5
Estimated H-index: 5
(CU: University of Colorado Boulder),
Brendan E. Depue17
Estimated H-index: 17
(CU: University of Colorado Boulder)
+ 2 AuthorsMarie T. Banich60
Estimated H-index: 60
(CU: University of Colorado Boulder)
Cite
Abstract
Although the relationship between structural differences within the prefrontal cortex (PFC) and executive function (EF) has been widely explored in cognitively impaired populations, little is known about this relationship in healthy young adults. Using optimized voxel-based morphometry (VBM), surface-based morphometry (SBM), and fractional anisotropy (FA) we determined the association between regional PFC grey matter (GM) morphometry and white matter tract diffusivity with performance on tasks that tap different aspects of EF as drawn from Miyake et al.’s three-factor model of EF. Reductions in both GM volume (VBM) and cortical folding (SBM) in the ventromedial PFC (vmPFC), ventrolateral PFC (vlPFC), and dorsolateral PFC (dlPFC) predicted better common EF, shifting-specific, and updating-specific performance, respectively. Despite capturing different components of GM morphometry, voxel- and surface-based findings were highly related, exhibiting regionally overlapping relationships with EF. Increased white matter FA in fiber tracts that connect the vmPFC and vlPFC with posterior regions of the brain also predicted better common EF and shifting-specific performance, respectively. These results suggest that the neural mechanisms supporting distinct aspects of EF may differentially rely on distinct regions of the PFC, and at least in healthy young adults, are influenced by regional morphometry of the PFC and the FA of major white matter tracts that connect the PFC with posterior cortical and subcortical regions.
  • References (125)
  • Citations (36)
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References125
Newest
Published on Dec 1, 2015
Donna M. McDonald-McGinn63
Estimated H-index: 63
(UPenn: University of Pennsylvania),
Kathleen E. Sullivan58
Estimated H-index: 58
(UPenn: University of Pennsylvania)
+ 9 AuthorsBernice E. Morrow5
Estimated H-index: 5
22q11.2 deletion syndrome is the most common chromosomal microdeletion disorder and is characterized by a heterogeneous presentation involving multiple organ systems. In this Primer, McDonald-McGinn et al. focus on the current understanding of the phenotype and the genetic underpinnings.
Published on Jan 1, 2014in Movement Disorders8.06
Yuanchao Zhang12
Estimated H-index: 12
(University of Electronic Science and Technology of China),
Jiuquan Zhang17
Estimated H-index: 17
(Third Military Medical University)
+ 5 AuthorsTianzi Jiang63
Estimated H-index: 63
(CAS: Chinese Academy of Sciences)
BackgroundParkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and non-motor symptoms. Previous morphometric studies of PD were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to the morphology of the cortical surface.
Published on Dec 1, 2013in Human Brain Mapping4.55
Ruth Ruscheweyh17
Estimated H-index: 17
,
Michael Deppe32
Estimated H-index: 32
+ 7 AuthorsStefan Knecht54
Estimated H-index: 54
(WWU: University of Münster)
Individual differences in executive functioning and brain morphology are considerable. In this study, we investigated their interrelation in a large sample of healthy older individuals. Digit span, trail-mak- ing, and Stroop tasks were used to assess different executive subfunctions in 367 nondemented community- dwelling individuals (50-81 years). Task performance was analyzed relative to brain structure using voxel- based morphometry, corrected for age and sex. Improved task performance was ass...
Published on Nov 1, 2013in Cerebral Cortex5.44
Larson J. Hogstrom1
Estimated H-index: 1
(University of Oslo),
Lars T. Westlye46
Estimated H-index: 46
(University of Oslo)
+ 1 AuthorsAnders M. Fjell55
Estimated H-index: 55
(University of Oslo)
Published on Jul 1, 2013in Brain Structure & Function3.62
Hikaru Takeuchi30
Estimated H-index: 30
(Tohoku University),
Yasuyuki Taki34
Estimated H-index: 34
(Tohoku University)
+ 4 AuthorsRyuta Kawashima60
Estimated H-index: 60
(Tohoku University)
Executive functions involve control processes such as goal-oriented planning, flexible strategy generation, sustaining set maintenance, self-monitoring, and inhibition. Executive functions during everyday events (EFEEs) are distinct from those measured under laboratory settings; the former can be severely impaired while the latter remain intact. Non-routine everyday problems due to executive dysfunctions affect individual functioning in everyday life and are of great clinical interest. Despite t...
Published on May 1, 2013in Cortex4.28
Aron Keith Barbey25
Estimated H-index: 25
,
Michael Koenigs30
Estimated H-index: 30
(UW: University of Wisconsin-Madison),
Jordan Grafman J97
Estimated H-index: 97
(Kessler Foundation)
Abstract Although neuroscience has made remarkable progress in understanding the involvement of prefrontal cortex (PFC) in human memory, the necessity of dorsolateral PFC (dlPFC) for key competencies of working memory remains largely unexplored. We therefore studied human brain lesion patients to determine whether dlPFC is necessary for working memory function, administering subtests of the Wechsler Memory Scale, the Wechsler Adult Intelligence Scale, and the N-Back Task to three participant gro...
Kimberlee D'Ardenne5
Estimated H-index: 5
,
Neir Eshel13
Estimated H-index: 13
+ 3 AuthorsJonathan D. Cohen118
Estimated H-index: 118
(Princeton University)
Humans are adept at switching between goal-directed behaviors quickly and effectively. The prefrontal cortex (PFC) is thought to play a critical role by encoding, updating, and maintaining internal representations of task context in working memory. It has also been hypothesized that the encoding of context representations in PFC is regulated by phasic dopamine gating signals. Here we use multimodal methods to test these hypotheses. First we used functional MRI (fMRI) to identify regions of PFC a...
Published on Dec 1, 2012in Cerebral Cortex5.44
Jean-Sebastien Provost7
Estimated H-index: 7
(UdeM: Université de Montréal),
Michael Petrides81
Estimated H-index: 81
(Montreal Neurological Institute and Hospital),
Oury Monchi30
Estimated H-index: 30
(UdeM: Université de Montréal)
Jean-Sebastien Provost, Michael Petrides, France Simard and Oury Monchi Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, 4565 Queen Mary Road, Montreal, Quebec H3W 1W5, Canada, Department of Radiology, University of Montreal, Montreal, Quebec H3C 3J7, Canada and Montreal Neurological Institute, Neuropsychology/Cognitive Neuroscience Unit, Rm 276, McGill University, Montreal, Quebec H3A 2B4, Canada
Published on Nov 1, 2012in NeuroImage5.81
Christoph P. Kaller21
Estimated H-index: 21
(University of Freiburg),
Katharina Heinze4
Estimated H-index: 4
(University of Freiburg)
+ 4 AuthorsLena Köstering9
Estimated H-index: 9
(University of Freiburg)
Abstract Planning of behavior relies on the integrity of the mid-dorsolateral prefrontal cortex (mid-dlPFC). Yet, only indirect evidence exists on the association of protracted maturation of dlPFC and continuing gains in planning performance post adolescence. Here, gray matter density of mid-dlPFC in young, healthy adults (18–32 years) was regressed onto performance on the Tower of London planning task while accounting for moderating effects of age and sex on this interrelation. Multiple regress...
Published on Jul 1, 2012in Human Brain Mapping4.55
Agnieszka Z. Burzynska13
Estimated H-index: 13
(MPG: Max Planck Society),
Irene E. Nagel16
Estimated H-index: 16
(FU: Free University of Berlin)
+ 5 AuthorsHauke R. Heekeren53
Estimated H-index: 53
(FU: Free University of Berlin)
Executive functions that are dependent upon the frontal-parietal network decline considerably during the course of normal aging. To delineate neuroanatomical correlates of age-related executive impairment, we investigated the relation between cortical thickness and executive functioning in 73 younger (20-32 years) and 56 older (60-71 years) healthy adults. Executive functioning was assessed using the Wisconsin Card Sorting Test (WCST). Cortical thickness was measured at each location of the cort...
Cited By36
Newest
Published on Jun 15, 2019in Human Brain Mapping4.55
Meng Heng Yang (NCKU: National Cheng Kung University), Zai Fu Yao , Shulan Hsieh15
Estimated H-index: 15
(NCKU: National Cheng Kung University)
Joseph M. Orr18
Estimated H-index: 18
(A&M: Texas A&M University),
Michael J. Imburgio1
Estimated H-index: 1
(A&M: Texas A&M University)
+ 1 AuthorsMarie T. Banich60
Estimated H-index: 60
(CU: University of Colorado Boulder)
During voluntary task selection, a number of internal and external biases may guide such a choice. However, it is not well understood how reward influences task selection when multiple options are possible. To address this issue, we examined brain activation in a voluntary task-switching paradigm while participants underwent fMRI (n = 19). To reinforce the overall goal to choose the tasks randomly, participants were told of a large bonus that they would receive at the end of the experiment for m...
Published on May 25, 2019in Nutritional Neuroscience3.95
Darel Wee Kiat Toh (NUS: National University of Singapore), Chun Hong Wong (NUS: National University of Singapore)+ 1 AuthorsJung Eun Kim (NUS: National University of Singapore)
ABSTRACTEssence of chicken (EC) is a dietary supplement with potential benefits on one’s cognitive performance. The purpose of this meta-analysis is to evaluate the effects of consuming EC on cognitive function, applying extensively represented domains. Six databases were systematically searched to yield 1760 articles. These articles were independently screened to obtain 8 eligible articles with a pooled population of 794 subjects which is more than twice the population size considered in the pr...
Published on Apr 3, 2019in Cognitive Neuroscience3.36
Delia Fuhrmann1
Estimated H-index: 1
(University of Cambridge),
Susanne Schweizer11
Estimated H-index: 11
(University of Cambridge)
+ 2 AuthorsSarah-Jayne Blakemore S-J64
Estimated H-index: 64
(UCL: University College London)
ABSTRACTAcademic diligence is the ability to regulate behavior in the service of goals, and a predictor of educational attainment. Here we combined behavioral, structural MRI, functional MRI and connectivity data to investigate the neurocognitive correlates of diligence. We assessed whether individual differences in diligence are related to the interplay between frontal control and striatal reward systems, as predicted by the dual-systems hypothesis of adolescent development. We obtained behavio...
Published on Apr 1, 2019in NeuroImage5.81
Christopher M. Weise10
Estimated H-index: 10
(Leipzig University),
Tobias Bachmann (Leipzig University)+ 1 AuthorsDorothee Saur22
Estimated H-index: 22
(Leipzig University)
Abstract Background The term executive functions (EF) describes a set of higher cognitive abilities/skills needed for goal-oriented and flexible behavior. In contrast to a multitude of functional neuroimaging studies of EF performance, only limited and partially inconclusive data is available for the structural-neuroanatomical underpinnings of EFs, particularly in healthy adults. Methods Here, we applied voxel-based morphometry (VBM) and additional analyses of cortical thickness (CTH; via surfac...
Published on Feb 1, 2019in American Journal of Neuroradiology3.26
S. Gohel (RU: Rutgers University), M.E. Laino (UCSC: Catholic University of the Sacred Heart)+ 6 AuthorsBehroze Vachha11
Estimated H-index: 11
BACKGROUND AND PURPOSE: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca9s area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between t...
Published on Jan 23, 2019in The Journal of Neuroscience6.07
Cassandra J. Lowe (MIND Institute), Amy C. Reichelt15
Estimated H-index: 15
(UWO: University of Western Ontario)
The modern “obesogenic” environment is characterized by an abundance of readily available hyperpalatable, energy-dense foods. These foods are highly valued and extremely rewarding: exposure to these foods and associated cues activates a diverse brain network underlying reward processing and
Published on 2018in Brain Structure & Function3.62
Eran Dayan11
Estimated H-index: 11
(UNC: University of North Carolina at Chapel Hill),
Virginia López-Alonso8
Estimated H-index: 8
(University of A Coruña)
+ 1 AuthorsLeonardo G. Cohen115
Estimated H-index: 115
(NIH: National Institutes of Health)
The link between the local structure of the primary motor cortex and motor function has been well documented. However, motor function relies on a network of interconnected brain regions and the link between the structural properties characterizing these distributed brain networks and motor function remains poorly understood. Here, we examined whether distributed patterns of brain structure, extending beyond the primary motor cortex can help classify two forms of motor function: corticospinal exc...
Published on Aug 1, 2018in NeuroImage5.81
Cassandra J. Lowe9
Estimated H-index: 9
(UW: University of Waterloo),
William R. Staines9
Estimated H-index: 9
(UW: University of Waterloo)
+ 1 AuthorsP. Hall25
Estimated H-index: 25
(UW: University of Waterloo)
Abstract Regulation of food cravings is thought to be critical for modulating eating behavior, yet we do not fully understand the mechanisms by which cognitive control operates in the eating context. The current study combined rTMS and EEG paradigms to examine the causal role of the left dorsolateral prefrontal cortex (dlPFC) in modulating visceral and behavioral responses to high calorie foods, and the mediational mechanisms underlying this relation. 28 right-handed female participants received...
Published on Jul 20, 2018in Frontiers in Human Neuroscience2.87
Harry R. Smolker5
Estimated H-index: 5
,
Naomi P. Friedman25
Estimated H-index: 25
+ 1 AuthorsMarie T. Banich60
Estimated H-index: 60
View next paperThe Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis