Match!

DNA self-assembly: prospectus and its future application

Published on May 1, 2010in Journal of Materials Science3.442
· DOI :10.1007/s10853-010-4237-6
Sathya Sadhasivam5
Estimated H-index: 5
,
Kyu Sik Yun1
Estimated H-index: 1
Sources
Abstract
The field of DNA nanotechnology has grown rapidly in the past 10 years, with many baby steps and exciting breakthroughs. DNA has recently been emerged as a versatile material for constructing artificial molecular structures and strategy which has excellent intrinsic characteristics, including programmability, self-organization, molecular recognition, and molecular-scale structuring properties, makes it an attractive nanoscale building material. Excitingly, DNA can be considered as a natural candidate for molecular self-assembly. In this review, we have focused on the methods for DNA self assembling patterns within the molecular fabric of DNA lattices.
  • References (88)
  • Citations (4)
📖 Papers frequently viewed together
14 Citations
3 Authors (Hanying Li, ..., Thomas H. LaBean)
103 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References88
Newest
#1Zhen-Gang WangH-Index: 45
#2Ofer I. WilnerH-Index: 15
Last. Itamar WillnerH-Index: 122
view all 3 authors...
Two kinds of circular DNA components are generated by the hybridization of short nucleic acids with the 3′ and 5′ ends of single-stranded DNA chains. The circular DNA components include, each, complementary domains for the anticocaine aptamer subunits, and sequence-specific domains for the auxiliary hybridization of programmed nucleic acid-functionalized proteins. The circular DNA components are self-assembled, in the presence of cocaine, into DNA nanowires (micrometer-long nanowires exhibiting ...
48 CitationsSource
#1David W. Grainger (UofU: University of Utah)H-Index: 50
DNA origami tiles can bind to shape-complementary sites on lithographically patterned surfaces.
7 CitationsSource
#1Ryan J. Kershner (UCSD: University of California, San Diego)H-Index: 1
#2Luisa D. Bozano (IBM)H-Index: 8
Last. Gregory M. Wallraff (IBM)H-Index: 27
view all 11 authors...
Artificial DNA nanostructures show promise for the organization of functional materials to create nanoelectronic or nano-optical devices. DNA origami, in which a long single strand of DNA is folded into a shape using shorter 'staple strands', can display 6-nm-resolution patterns of binding sites, in principle allowing complex arrangements of carbon nanotubes, silicon nanowires, or quantum dots. However, DNA origami are synthesized in solution and uncontrolled deposition results in random arrange...
262 CitationsSource
Brings the latest advances in nanotechnology and biology to computing This pioneering book demonstrates how nanotechnology can create even faster, denser computing architectures and algorithms. Furthermore, it draws from the latest advances in biology with a focus on bio-inspired computing at the nanoscale, bringing to light several new and innovative applications such as nanoscale implantable biomedical devices and neural networks. Bio-Inspired and Nanoscale Integrated Computing features an exp...
18 CitationsSource
#1Shawn M. Douglas (Wyss Institute for Biologically Inspired Engineering)H-Index: 12
#2Hendrik Dietz (Harvard University)H-Index: 33
Last. William M. Shih (Wyss Institute for Biologically Inspired Engineering)H-Index: 37
view all 6 authors...
DNA has proved to be a versatile building block in the creation of complex structures through self-assembly, exploiting the intermolecular forces between the components. Here, the arrangement of DNA helices on pleated strands which are then assembled into honeycomb-like three-dimensional structures, produces objects of unprecedented complexity.
1,288 CitationsSource
#1Ofer I. WilnerH-Index: 15
#2Simcha ShimronH-Index: 10
Last. Itamar WillnerH-Index: 122
view all 5 authors...
DNA strands consisting of programmed sequence-specific domains were synthesized by the rolling circle amplification (RCA) process. The spatial positioning of glucose oxidase (GOx) and of horseradish peroxidase (HRP) on the RCA-synthesized DNA template via hybridization enabled the activation of the bienzyme cascade. The GOx-catalyzed oxidation of glucose yielded gluconic acid and H2O2, and the resulting H2O2 oxidized 2,2′-azino-bis[3-ethylbenzthiazoline-6-sulfonic-acid] (ABTS2−) in the presence ...
78 CitationsSource
#1Hanying Li (Duke University)H-Index: 8
#2Joshua D. Carter (Duke University)H-Index: 4
Last. Thomas H. LaBean (Duke University)H-Index: 36
view all 3 authors...
Molecular self-assembly strategies involve the formation of nanometer scale objects and materials in the absence of significant external control. One increasingly popular self-assembly approach makes use of the unique properties of deoxyribonucleic acid (DNA) including its diminutive size and high capacity for information storage. For many applications, DNA stands alone as the top choice for the programmable construction of supramolecular materials due to its specific and well-understood base-pa...
103 CitationsSource
#1Ofer I. Wilner (HUJI: Hebrew University of Jerusalem)H-Index: 15
#2Yossi Weizmann (HUJI: Hebrew University of Jerusalem)H-Index: 31
Last. Itamar Willner (HUJI: Hebrew University of Jerusalem)H-Index: 122
view all 6 authors...
Predicting and controlling the functions in self-organized biomolecular nanostructures is a major challenge in systems biology. Now researchers have developed DNA scaffolds for the topological organization of different enzymes or cofactor-enzyme pairs. The organization of the biomolecules leads to the activation of enzyme cascades that do not occur in non-organized mixtures, and the reactivity of the system can be controlled by the DNA template.
377 CitationsSource
#1Jaswinder Sharma (ASU: Arizona State University)H-Index: 24
#2Rahul Chhabra (ASU: Arizona State University)H-Index: 13
Last. Hao Yan (ASU: Arizona State University)H-Index: 79
view all 6 authors...
The assembly of nanoparticles into three-dimensional (3D) architectures could allow for greater control of the interactions between these particles or with molecules. DNA tubes are known to form through either self-association of multi-helix DNA bundle structures or closing up of 2D DNA tile lattices. By the attachment of single-stranded DNA to gold nanoparticles, nanotubes of various 3D architectures can form, ranging in shape from stacked rings to single spirals, double spirals, and nested spi...
501 CitationsSource
#1Peng Yin (California Institute of Technology)H-Index: 37
#2Rizal F. Hariadi (California Institute of Technology)H-Index: 11
Last. John H. Reif (Duke University)H-Index: 55
view all 7 authors...
Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.
278 CitationsSource
Cited By4
Newest
#1Murugan Veerapandian (Gachon University)H-Index: 19
#2Sathya Sadhasivam (Gachon University)H-Index: 5
Last. Kyusik Yun (KIST: Korea Institute of Science and Technology)H-Index: 22
view all 4 authors...
Source
#1Vikram Singh (DU: University of Delhi)H-Index: 11
#2Michael Zharnikov (Heidelberg University)H-Index: 42
Last. Tarkeshwar Gupta (DU: University of Delhi)H-Index: 8
view all 4 authors...
Progress in bio-molecular chemistry, nanotechnology, and surface engineering resulted in the fabrication of nanoscale bio-systems with advanced functionalities. These systems and the related methodologies offer new perspectives for the development of novel bio-related diagnostic tools and gene and/or photodynamic therapy. A key issue in this context is the design and fabrication of “smart surfaces” able to immobilize functional biomolecules and DNA in particular, which can perform a certain func...
14 CitationsSource
#1Keita Sakakibara (National Institute for Materials Science)H-Index: 14
#2Jonathan P. Hill (National Institute for Materials Science)H-Index: 56
Last. Katsuhiko Ariga (National Institute for Materials Science)H-Index: 93
view all 3 authors...
Controlling the organization of molecular building blocks at the nanometer level is of utmost importance, not only from the viewpoint of scientific curiosity, but also for the development of next-generation organic devices with electrical, optical, chemical, or biological functions. Self-assembly offers great potential for the manufacture of nanoarchitectures (nanostructures and nanopatterns) over large areas by using low-energy and inexpensive spontaneous processes. However, self-assembled stru...
128 CitationsSource