Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts

Objectives We aimed to define the effects of peroxisomal proliferator-activated receptor γ (PPARγ) and PPARα agonist mono and combination therapy on adipose tissue and skeletal muscle gene expression in relation to insulin sensitivity. We further investigated the role of genetic polymorphisms in PPAR ligand-modulated genes in transcriptional regulation and glucose homeostasis. Materials and methods Genome-wide transcript profiles of subcutaneous...