Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Science56.90
Volume: 332, Issue: 6026, Pages: 243 - 247
Published: Apr 8, 2011
Abstract
Eosinophils are associated with helminth immunity and allergy, often in conjunction with alternatively activated macrophages (AAMs). Adipose tissue AAMs are necessary to maintain glucose homeostasis and are induced by the cytokine interleukin-4 (IL-4). Here, we show that eosinophils are the major IL-4-expressing cells in white adipose tissues of mice, and, in their absence, AAMs are greatly attenuated. Eosinophils migrate into adipose tissue by...
Paper Details
Title
Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis
Published Date
Apr 8, 2011
Journal
Volume
332
Issue
6026
Pages
243 - 247
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