Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Nutrigenomic Studies of Effects of Chlorella on Subjects with High-Risk Factors for Lifestyle-Related Disease

Published on Sep 1, 2008in Journal of Medicinal Food 1.95
· DOI :10.1089/jmf.2006.0180
Toru Mizoguchi4
Estimated H-index: 4
,
Isao Takehara1
Estimated H-index: 1
+ 2 AuthorsYo Naoki3
Estimated H-index: 3
Abstract
ABSTRACT In order to clarify the physiological effects of Chlorella intake on subjects with high-risk factors for lifestyle-related diseases, we conducted Chlorella ingestion tests on 17 subjects with high-risk factors for lifestyle-related diseases and 17 healthy subjects over a 16-week period, including a 4-week post-observation period. We conducted blood biochemical tests and analyzed gene expression profile in whole blood cells in the peripheral blood before and after Chlorella intake. We confirmed that in both groups, Chlorella intake resulted in noticeable reductions in body fat percentage, serum total cholesterol, and fasting blood glucose levels. Through gene expression analysis, we found that gene expression profiles varied with Chlorella intake and identified many genes that exhibited behavior such that after the completion of the intake period, expression levels returned to pre-intake expression ones. Among these were genes related to signal transduction molecules, metabolic enzymes, receptors,...
  • References (18)
  • Citations (31)
Cite
References18
Newest
Published on Jun 1, 2006in Journal of The American College of Nutrition 2.17
Steven H. Woolf56
Estimated H-index: 56
(VCU: Virginia Commonwealth University)
Dietary guidelines have broad implications for the health of individuals and populations. Increasingly, government agencies and medical organization that issue guidelines have pursued evidence-based approaches. These approaches emphasize a comprehensive, critical, and explicit examination of the scientific evidence that the proposed dietary practice will improve health. Evidence-based guidelines typically feature an explicit methodology, include as their foundation a systematic review of the evi...
14 Citations Source Cite
Lydia A. Afman20
Estimated H-index: 20
,
Michael Müller94
Estimated H-index: 94
Abstract Until recently, nutrition research concentrated on nutrient deficiencies and impairment of health. The advent of genomics—interpreted broadly as a suite of high throughput technologies for the generation, processing, and application of scientific information about the composition and functions of genomes—has created unprecedented opportunities for increasing our understanding of how nutrients modulate gene and protein expression and ultimately influence cellular and organismal metabolis...
215 Citations Source Cite
Published on Feb 1, 2006in Life Sciences 3.23
Jong-Yuh Cherng14
Estimated H-index: 14
(CCU: National Chung Cheng University),
Mei-Fen Shih7
Estimated H-index: 7
(CNU: Chia Nan University of Pharmacy and Science)
Abstract Chlorella , a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have not been studied. Diabetes in ICR mice was induced by injection of STZ. Lipogenesis in vivo was measured by incorporating 3 H–H 2 O into lipids in brown and white adipose ...
40 Citations Source Cite
Published on Jul 1, 2005in Life Sciences 3.23
You-Hong Cheng4
Estimated H-index: 4
(Cincinnati Children's Hospital Medical Center),
Stuart Handwerger13
Estimated H-index: 13
(Cincinnati Children's Hospital Medical Center)
Corticotropin-releasing hormone (CRH) gene expression in human placental cells is induced by activation of the cyclic AMP and protein kinase C signal transduction pathways, but the role of the mitogen-activated kinase (MAPK) pathway is unknown. In this study, we showed that the MAPK inhibitor, PD098059, causes a dose-dependent inhibition of placental CRH gene expression. In contrast, overexpression of RAF in human choriocarcinoma JEG cells stimulates CRH promoter activity by 15-fold, and the sti...
13 Citations Source Cite
Published on Jul 1, 2005in Life Sciences 3.23
Cherng Jong-Yuh2
Estimated H-index: 2
(CNU: Chia Nan University of Pharmacy and Science),
Shih Mei-Fen1
Estimated H-index: 1
(CNU: Chia Nan University of Pharmacy and Science)
Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Chlorella has been shown to produce hypoglycemic effects in alloxan-induced diabetic animals. However, there are no other reports of the effects of this substance in other diabetic animal models. Here we have used streptozocin (STZ)-induced diabetic mice to study the thypoglycemic effects of Chlorella. Diabetes was induced in ICR strain mice by the i.p. injection of STZ. Vehicle-treated ICR mice...
55 Citations Source Cite
Published on Mar 1, 2005in Cytometry Part A 3.26
George Dimitriadis27
Estimated H-index: 27
(Athens State University),
Eirini Maratou19
Estimated H-index: 19
+ 3 AuthorsSotirios A. Raptis38
Estimated H-index: 38
(Athens State University)
Background We investigated the effects of insulin on glucose transport in human monocytes using flow cytometry, a method with several advantages over previously used techniques. We hypothesized that monocytes could be used as tools to study insulin action at the cellular level and facilitate the investigation of mechanisms that lead to insulin resistance. Methods Blood was withdrawn from 38 healthy subjects. The expression of glucose transporter (GLUT) isoforms in plasma membrane and the rates o...
45 Citations Source Cite
Published on Jun 1, 2004in Journal of Medicinal Food 1.95
Fong-Chi Cheng6
Estimated H-index: 6
,
Atsui Lin6
Estimated H-index: 6
+ 5 AuthorsYo Naoki3
Estimated H-index: 3
A Chlorella powder was screened using 52 in vitro assay systems for enzyme activity, receptor binding, cellular cytokine release, and B and T cell proliferation. The screening revealed a very potent inhibition of human protein tyrosine phosphatase (PTP) activity of CD45 and PTP1C with 50% inhibitory concentration (IC50) values of 0.678 and 1.56 μg/mL, respectively. It also showed a moderate inhibition of other PTPs, including PTP1B (IC50 = 65.3 μg/mL) and T-cell-PTP (114 μg/mL). Other inhibitory...
16 Citations Source Cite
Published on Jun 1, 2004in Physiology 5.95
Michael Roden1
Estimated H-index: 1
Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.
125 Citations Source Cite
Published on Jan 1, 2001in Alternative Therapies in Health and Medicine 1.01
Randall E. Merchant21
Estimated H-index: 21
,
Cynthia A. Andre3
Estimated H-index: 3
ContextIt has been suggested that the consumption of natural "whole foods" rich in macronutrients has many healthful benefits for those who otherwise ingest a normal, nonvegetarian diet. One example is dietary supplements derived from Chlorella pyrenoidosa, a unicel- lular fresh water green alga rich in proteins, vitamins, and minerals. ObjectiveTo find evidence of the potential of chlorella dietary sup- plements to relieve signs and symptoms, improve quality of life, and normalize body function...
62 Citations
Published on Jan 1, 2001in Journal of Nutritional Science and Vitaminology 0.95
Shinya Shibata2
Estimated H-index: 2
,
Kuniaki Oda1
Estimated H-index: 1
+ 5 AuthorsHiroshi Sansawa2
Estimated H-index: 2
The effects of Chlorella regularis powder (CP) and Chlorella regularis indigestible fraction (CIF) on serum and liver lipid concentrations and on fecal steroid excretion were es-timated in rats fed diets containing 5 g/kg cholesterol and 2.5 g/kg sodium cholate. The in-gestion of 12.7% CP or 5.3% CIF did not influence food intake or growth. CP and CIF de-creased the levels of serum cholesterol, but had no effect on the levels of serum triacylglyc-erol and phospholipid. Liver cholesterol contents...
30 Citations Source Cite
Cited By31
Newest
Published on Jul 1, 2019in Nutrition 3.73
Naoki Horii3
Estimated H-index: 3
(Rits: Ritsumeikan University),
Natsuki Hasegawa6
Estimated H-index: 6
(Rits: Ritsumeikan University)
+ 4 AuthorsMotoyuki Iemitsu33
Estimated H-index: 33
(Rits: Ritsumeikan University)
Abstract Objectives Chlorella is a type of unicellular green algae that contains various nutrients. Habitual exercise and chlorella treatment can improve insulin resistance in obese or diabetic animal models. However, the additive effects of combined chlorella intake and aerobic exercise training remain unclear. The aim of this study was to investigate whether a combination of chlorella intake and aerobic exercise training would produce greater effects on improving glycemic control in rats with ...
Source Cite
Published on Apr 29, 2019in Critical Reviews in Food Science and Nutrition 6.20
Negar Jamshidi1
Estimated H-index: 1
(RMIT: RMIT University),
Nitin Mantri14
Estimated H-index: 14
(RMIT: RMIT University),
Marc Cohen20
Estimated H-index: 20
(RMIT: RMIT University)
AbstractThe health benefits of long-term dietary plant ingestion are well-established. However, literature on acute nutritional challenges is very limited. This study aimed to identify available evidence on transcriptomics responses to acute ingestion of plants or plant extracts and identify signature gene profiles that may serve as biomarkers of health status. We systematically searched electronic databases and extracted information based-on inclusion criteria such as human clinical studies, si...
Source Cite
Published on Apr 1, 2018
Ulrike Neumann3
Estimated H-index: 3
,
Stephan C. Bischoff60
Estimated H-index: 60
Unter Mikroalgen fasst man mikroskopisch kleine, Fotosynthese betreibende Organismen zusammen, die in aquatischen Umgebungen vorkommen. Sie enthalten eine Vielzahl von Nahrstoffen, darunter auch Proteine, Kohlenhydrate, Carotinoide, Vitamine, Mineralstoffe und Fettsauren. In Lebensmitteln verarbeitet findet man heutzutage vor allem die Grunalge Chlorella und das Cyanobakterium Arthrospira. Die steigende Weltbevolkerung bei gleichzeitig begrenztem Ackerland wird in den nachsten Jahren zu einer no...
Source Cite
Published on Jan 1, 2018
Source Cite
Published on Aug 1, 2017in Clinical Nutrition 5.50
Mehrangiz Ebrahimi-Mameghani6
Estimated H-index: 6
(Tabriz University of Medical Sciences),
Zahra Sadeghi1
Estimated H-index: 1
+ 2 AuthorsSoodabeh Aliashrafi3
Estimated H-index: 3
(Tabriz University of Medical Sciences)
Summary Background Chlorella vulgaris ( C . vulgaris ) is reported to improve dyslipidemia and hypertension; however, its effect on inflammatory biomarkers and insulin resistance has not been noticed thus far. Non-alcoholic fatty liver disease (NAFLD) as a hepatic symptom of metabolic syndrome is strongly associated with insulin resistance and inflammation. Aim of the study In the current interventional trial, we aimed to study the effects of C. vulgaris supplementation on glucose homeostasis, i...
6 Citations Source Cite
Published on Jun 1, 2017in Journal of Separation Science 2.42
Jianbing Wu1
Estimated H-index: 1
,
Chunping Liu1
Estimated H-index: 1
(ZJSU: Zhejiang Gongshang University),
Yanbin Lu13
Estimated H-index: 13
(ZJSU: Zhejiang Gongshang University)
The unicellular alga Chlorella vulgaris is a well-known health food. It has been proven that the minor phytosterols, ergosterol and its analogue, are an important class of bioactive substances in C. vulgaris. In this work, a recycling counter-current chromatographic approach was proposed for preparative separation of two analogue sterols from crude extract of C. vulgaris. The separation unit was set up with a type-J instrument coupled with a column switching valve. A two-phase solvent system com...
2 Citations Source Cite
Published on Mar 23, 2017in Marine Drugs 4.38
En-Qin Xia1
Estimated H-index: 1
,
Shanshan Zhu2
Estimated H-index: 2
+ 3 AuthorsTang-Bin Zou2
Estimated H-index: 2
An increasing prevalence of diabetes is known as a main risk for human health in the last future worldwide. There is limited evidence on the potential management of type 2 diabetes mellitus using bioactive peptides from marine organisms, besides from milk and beans. We summarized here recent advances in our understanding of the regulation of glucose metabolism using bioactive peptides from natural proteins, including regulation of insulin-regulated glucose metabolism, such as protection and repa...
5 Citations Source Cite
Published on Jan 1, 2017
Source Cite