DNA Methylation Signatures Identify Biologically Distinct Thyroid Cancer Subtypes

The purpose of this study was to determine the global patterns of aberrant DNA methylation in thyroid cancer. We have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of papillary, follicular, medullary, and anaplastic thyroid tumors. We identified 262 and 352 hypermethylated and 13 and 21 hypomethylated genes in differentiated papillary and follicular tumors, respectively. Interestingly,...