Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
Abstract
Objectives null Thoracic aneurysms are the main cardiovascular complication of Marfan syndrome (MFS) resulting in premature death. MFS has been associated with mutations of the gene encoding fibrillin-1 (FBN1), a major constituent of the elastic fibers. Matrix metalloproteinases (MMPs) are important in the pathogenesis of abdominal aortic aneurysms but their precise role in MFS is not clear. Doxycycline is a nonspecific MMP inhibitor. The...
Paper Details
Title
Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome
Published Date
Jan 1, 2008
Journal
Volume
47
Issue
1
Pages
166 - 172
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