Rhodium(III) and iridium(III) complexes as anticancer agents

Until recently, Rh(III) and particularly Ir(III) complexes were generally considered as being unlikely candidates for anticancer agents owing to the typical kinetic inertness of their transition metal centres. Systematic studies on the cellular impact of a range of octahedral Rh(III) complexes containing polypyridyl and other aromatic chelates have now, however, demonstrated that high cytotoxicity in cancer cells and in certain cases promising...