Review paper
Tn5 Transposase-Mediated Mouse Transgenesis1
Abstract
We have developed a novel method for mouse transgenesis. The procedure relies on a hyperactive Tn5 transposase to insert a transgene into mouse chromosomes during intracytoplasmic sperm injection. This procedure integrates foreign DNA into the mouse genome with dramatically increased effectiveness as compared to conventional methods such as pronuclear microinjection and traditional sperm injection-mediated transgenesis. Our data indicate that...
Paper Details
Title
Tn5 Transposase-Mediated Mouse Transgenesis1
Published Date
Dec 1, 2005
Journal
Volume
73
Issue
6
Pages
1157 - 1163
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