UPREGULATION OF BONE MORPHOGENETIC PROTEIN GDF-3/Vgr-2 EXPRESSION IN ADIPOSE TISSUE OF FABP4/aP2 NULL MICE

High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling molecules similar to leptin. To test this hypothesis, proteomic analysis of serum proteins from high-fat-fed wild-type and...