Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Metazoan organisms are dependent on a continuous supply of O 2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca 2+ signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis,...