Molecular Genetics of Monoamine Transporters: Relevance to Brain Disorders
Abstract
We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains. We have demonstrated that these domains can act as both tissue-specific and stimulus-inducible regulators of gene...
Paper Details
Title
Molecular Genetics of Monoamine Transporters: Relevance to Brain Disorders
Published Date
Oct 25, 2007
Journal
Volume
33
Issue
4
Pages
652 - 667
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