2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

Published on Jan 1, 2013in Arthritis & Rheumatism9.002
· DOI :10.1002/art.37715
J. C. Jennette3
Estimated H-index: 3
(UNC: University of North Carolina at Chapel Hill),
Ronald J. Falk73
Estimated H-index: 73
(UNC: University of North Carolina at Chapel Hill)
+ 25 AuthorsRichard A. Watts50
Estimated H-index: 50
(UEA: University of East Anglia)
2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides J. Jennette;R. Falk;P. Bacon;N. Basu;M. Cid;F. Ferrario;L. Flores-Suarez;W. Gross;L. Guillevin;E. Hagen;G. Hoffman;D. Jayne;C. Kallenberg;P. Lamprecht;C. Langford;R. Luqmani;A. Mahr;E. Matteson;P. Merkel;S. Ozen;C. Pusey;N. Rasmussen;A. Rees;D. Scott;U. Specks;J. Stone;K. Takahashi;R. Watts; Arthritis & Rheumatism
Figures & Tables
  • References (22)
  • Citations (2020)
📖 Papers frequently viewed together
28 Authors (J. C. Jennette, ..., Richard A. Watts)
455 Citations
1,027 Citations
309 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Anne EdwardsH-Index: 2
#2Robin TalbotH-Index: 2
171 CitationsSource
#1Peter C. Grayson (BU: Boston University)H-Index: 18
#2Kathleen Maksimowicz-McKinnon (Cleveland Clinic)H-Index: 20
Last. Peter A. Merkel (BU: Boston University)H-Index: 71
view all 14 authors...
Objectives To compare patterns of arteriographic lesions of the aorta and primary branches in patients with Takayasu9s arteritis (TAK) and giant cell arteritis (GCA). Methods Patients were selected from two North American cohorts of TAK and GCA. The frequency of arteriographic lesions was calculated for 15 large arteries. Cluster analysis was used to derive patterns of arterial disease in TAK versus GCA and in patients categorised by age at disease onset. Using latent class analysis, computer de...
143 CitationsSource
PURPOSE OF REVIEW: To clearly define single-organ vasculitis (SOV) and distinguish diffuse from focal SOV. To delineate clinical, laboratory, and histopathological features useful in differentiating focal SOV from systemic vasculitis affecting the same territory. RECENT FINDINGS: SOV may affect organs in a diffuse or multifocal fashion (e.g. central nervous system and skin) or may be confined to focal sites (e.g. breast, gynecologic, testicular, and abdominal structures, and the aorta). Because ...
43 CitationsSource
#1Hitoshi SuzukiH-Index: 32
#2Krzysztof KirylukH-Index: 28
Last. Bruce A. Julian (UAB: University of Alabama at Birmingham)H-Index: 67
view all 11 authors...
Here we discuss recent advances in understanding the biochemical, immunologic, and genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis. Current data indicate that at least four processes contribute to development of IgA nephropathy. Patients with IgA nephropathy often have a genetically determined increase in circulating levels of IgA1 with galactose-deficient O-glycans in the hinge-region (Hit 1). This glycosylation aberrancy is, however, not sufficient to induce...
254 CitationsSource
#1Ruth M. Tarzi (Imperial College London)H-Index: 13
#2H. Terence Cook (Imperial College London)H-Index: 60
Last. Charles D. Pusey (Imperial College London)H-Index: 72
view all 3 authors...
Summary This review provides a summary of recent advances in the understanding of crescentic glomerulonephritis, focusing on antineutrophil cytoplasm antibody (ANCA)-associated vasculitis and anti–glomerular basement membrane (anti-GBM) antibody disease. In ANCA-associated vasculitis (AAV), four main conceptual advances are discussed as follows: (1) evidence for the pathogenicity of ANCA, (2) molecular mimicry and the role of infection in AAV, (3) evidence for aberrant T-cell responses and T-cel...
43 CitationsSource
#1Ronald J. Falk (UNC: University of North Carolina at Chapel Hill)H-Index: 73
#2Wolfgang L. Gross (University of Lübeck)H-Index: 78
Last. Richard A. Watts (National Health Service)H-Index: 50
view all 13 authors...
The Boards of Directors of the American College of Rheumatology, the American Society of Nephrology, and the European League Against Rheumatism recommend a gradual shift from honorific eponyms to diseasedescriptive or etiology-based nomenclature. The leadership of these three organizations tasked an international group of senior academicians expert in the care of patients with vasculitis and engaged in research in the field to provide the medical community with proper descriptive terms instead o...
206 CitationsSource
Purpose of reviewIn last few years, there have been significant advances in our understanding of a newly recognized condition known as IgG4-related systemic disease. This review will focus on IgG4-related systemic disease as a cause of thoracic aortitis, inflammatory abdominal aortic aneurysm or per
160 CitationsSource
#1Ronald J. FalkH-Index: 73
#2Wolfgang L. GrossH-Index: 78
Last. Richard A. WattsH-Index: 50
view all 13 authors...
22 Citations
Objective To identify patients with localised Wegener9s granulomatosis (locWG) to assess whether it occurs as a long-term disease stage or phenotype and to characterise its outcome. Methods Patients in a ‘localised stage’ with histological criteria compatible with WG and a follow-up period of ≥1 year were included. They were prospectively followed at the Vasculitis Center Schleswig-Holstein from 1989 to 2009 and the clinical manifestations, antineutrophil cytoplasmic autoantibodies (ANCA) status...
129 CitationsSource
#1Min Chen (PKU: Peking University)H-Index: 27
ANCA-associated vasculitides (AAV) involve inflammation and fibrinoid necrosis of the vessel wall. This Review highlights advances in our understanding of the cells and molecules that contribute to AAV pathogenesis and discusses new developments in the treatment of these diseases.
98 CitationsSource
Cited By2020
#1Tetsuya Abe (Kitasato University)H-Index: 1
#2Keiko Nishiyama (Kitasato University)
Last. Mariko Kamata (Kitasato University)H-Index: 5
view all 14 authors...
Carbamazepine-induced acute kidney injury is mainly caused by acute tubulointerstitial nephritis. Only one case of carbamazepine-induced eosinophilic granulomatosis with polyangiitis (EGPA) with acute kidney injury has been reported. But the patient’s condition improved with the immediate discontinuation of carbamazepine. We present a case requiring hemodialysis and steroid therapy for carbamazepine-induced EGPA with acute kidney injury. A 77-year-old man with allergic rhinitis was prescribed ca...
#1Lu Zhao (CSU: Central South University)
#2Liang Peng (CSU: Central South University)
Last. Hong Liu (CSU: Central South University)H-Index: 53
view all 10 authors...
Abstract Background Immunoglobulin A nephropathy (IgAN nephropathy, IgAN) is named for the renal pathological features of IgA-dominant immunoglobulin deposition. IgA deposits, however, may also occur in other diseases, from liver disease and inflammation to chronic infections and tumors. Now increasing studies have suggested that galactose-deficient IgA1 (Gd-IgA1) plays a critical role in the pathogenesis of IgAN. This study aims to investigate whether the Gd-IgA1-specific antibody KM55 contribu...
#1Soo Bin Lee (Yonsei University)H-Index: 2
#2Hyeok Choi (Yonsei University)H-Index: 2
Last. Somin Lee (Yonsei University)H-Index: 33
view all 7 authors...
We investigated the clinical implication of ANCA positivity at diagnosis on the poor outcomes in patients with Sjogren’s syndrome. The medical records of 606 Korean patients with Sjogren’s syndrome were retrospectively reviewed. The results of perinuclear (P)-ANCA, myeloperoxidase (MPO)-ANCA, cytoplasmic (C)-ANCA, and proteinase 3 (PR3)-ANCA were collected and the frequencies of all-cause mortality, interstitial lung disease (ILD), end-stage renal disease (ESRD), and lymphoma were assessed as th...
#1Yukinobu Ito (Akita University)H-Index: 2
#2Makoto Yoshida (Akita University)H-Index: 5
Last. Akiteru Goto (Akita University)H-Index: 25
view all 10 authors...
Abstract Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or non-granulomatous extravascular eosinophilic inflammation. EGPA preferentially affects certain organ systems, including the airways, peripheral nerves, heart, kidney, and gastrointestinal tract. Although gastrointestinal involvement, such as ulceration...
1 CitationsSource
#1Luka Bolha (University of Ljubljana)H-Index: 4
#2Jože Pižem (University of Ljubljana)H-Index: 8
Last. Vesna Jurčić (University of Ljubljana)H-Index: 8
view all 6 authors...
OBJECTIVES To identify dysregulated microRNAs (miRNAs) and their gene targets in temporal arteries from GCA patients, and determine their association with GCA pathogenesis and related arterial wall remodelling. METHODS We included 93 formalin-fixed, paraffin-embedded temporal artery biopsies (TABs) from treatment-naive patients: 54 positive and 17 negative TABs from clinically proven GCA patients, and 22 negative TABs from non-GCA patients. miRNA expression analysis was performed with miRCURY LN...
#1Anthony Fong (UQ: University of Queensland)H-Index: 2
#2Shahzada Ahmed (University Hospitals Birmingham NHS Foundation Trust)H-Index: 3
Last. Susan P. Mollan (Queen Elizabeth Hospital Birmingham)H-Index: 16
view all 6 authors...
#1Rona Smith (University of Cambridge)H-Index: 13
#2Rachel Bronwen Jones (Cambridge University Hospitals NHS Foundation Trust)H-Index: 2
Last. Simon Carette (U of T: University of Toronto)H-Index: 24
view all 46 authors...
Objectives Evaluation of rituximab and glucocorticoids as therapy to induce remission after relapse in ANCA-associated vasculitis (AAV) in a prospective observational cohort of patients enrolled into the induction phase of the RITAZAREM trial. Methods Patients relapsing with granulomatosis with polyangiitis or microscopic polyangiitis were prospectively enrolled and received remission-induction therapy with rituximab (4×375 mg/m2) and a higher or lower dose glucocorticoid regimen, depending on p...
#1Javier VillacortaH-Index: 6
#2Laura Lucientes (Complutense University of Madrid)
Last. Gema Fernandez-JuarezH-Index: 9
view all 10 authors...
#1Mikiko Kobayashi (Shinshu University)H-Index: 4
#2Yuki Matsumoto (Shinshu University)
Last. Hiroyuki Kanno (Shinshu University)H-Index: 9
view all 7 authors...
The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. Macrophages are among the major inflammatory cells involved in innate immunity and are classified into M1 and M2 subtypes. M1-type macrophages kill pathogens and cause inflammation, ...