Total Sleep Deprivation Alters Endothelial Function in Rats: A Nonsympathetic Mechanism

Sleep loss is suspected to induce endothelial dysfunction, a key factor in cardiovascular risk. We examined whether sympathetic activity is involved in the endothelial dysfunction caused by total sleep deprivation (TSD). Two groups: TSD (24-h wakefulness), using slowly rotating wheels, and wheel control (WC). Seven-month-old male Wistar rats. Pharmacological sympathectomy (reserpine, 5 mg/kg, intraperitoneal), nitric oxide synthase (NOS)...