Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Abstract
Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate that messages delivered by microvesicles are translated by recipient cells. These microvesicles are also enriched in angiogenic proteins and stimulate...
Paper Details
Title
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Published Date
Nov 16, 2008
Journal
Volume
10
Issue
12
Pages
1470 - 1476
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