Is visceral obesity the cause of the metabolic syndrome

Published on Jan 1, 2006in Annals of Medicine3.05
· DOI :10.1080/07853890500383895
Jean-Pierre Després110
Estimated H-index: 110
Despite the fact that controversy remains around the underlying pathophysiological processes leading to the development of the metabolic syndrome (insulin resistance and/or hyperinsulinemia versus abdominal obesity), there is increased recognition that abdominal obesity is the most prevalent form of the metabolic syndrome. Although it has been well established that there is a greater prevalence of chronic metabolic diseases such as diabetes and cardiovascular diseases in obese patients than among normal weight individuals, obesity is a remarkably heterogeneous condition and not every obese patient is characterized by co‐morbidities. In this regard, body fat distribution, especially visceral adipose tissue accumulation, has been found to be a major correlate of a cluster of diabetogenic, atherogenic, prothrombotic and proinflammatory metabolic abnormalities referred to as the metabolic syndrome. Due to its anatomic location and peculiar metabolic, hyperlipolytic activity, the expanded visceral adipose depo...
  • References (99)
  • Citations (464)
Published on Sep 1, 2005in The Lancet59.10
K. George M.M. Alberti33
Estimated H-index: 33
Paul Zimmet108
Estimated H-index: 108
Jonathan E. Shaw90
Estimated H-index: 90
Published on Sep 1, 2005in Diabetes Care15.27
John M. Miles40
Estimated H-index: 40
Michael Dennis Jensen68
Estimated H-index: 68
It has been known for over half a century that accumulation of fat in the upper body is associated with metabolic complications of obesity. The mechanism responsible for this association is widely believed to be insulin resistance, which is frequently present in individuals with upper-body obesity (1) and is associated with increased cardiovascular risk (2). The upper-body obesity phenotype is accompanied by increased free fatty acid (FFA) flux and concentration, whereas individuals with predomi...
Published on Sep 1, 2005in Diabetologia7.11
Edwin A M Gale46
Estimated H-index: 46
(UoB: University of Bristol)
Published on Sep 1, 2005in Diabetes Care15.27
Richard Kahn39
Estimated H-index: 39
(American Diabetes Association),
John B. Buse93
Estimated H-index: 93
(UNC: University of North Carolina at Chapel Hill)
+ 1 AuthorsMichael P. Stern91
Estimated H-index: 91
(University of Texas Health Science Center at San Antonio)
The term “metabolic syndrome” refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance. Since the term is widely used in research and clinical practice, we undertook an extensive review of the literature in relation to the syndrome’s definition, underlying pathogenesis, and association with CVD and to the goals and impact of treatment. While there is no question that certain CVD risk factors are p...
Published on Mar 1, 2005in The Journal of Clinical Endocrinology and Metabolism5.61
Mélanie Côté31
Estimated H-index: 31
Pascale Mauriège37
Estimated H-index: 37
+ 4 AuthorsJean-Pierre Després110
Estimated H-index: 110
The present study examined the associations between a major adipokine, adiponectin, and adiposity indices as well as metabolic risk variables in a sample of 190 untreated asymptomatic men. Anthropometric measurements and a complete fasting plasma lipoprotein and lipid profile were obtained, and subjects underwent an oral glucose tolerance test. Fasting plasma adiponectin concentrations were determined by an ELISA. Although all adiposity and adipose tissue (AT) distribution indices were negativel...
Published on Sep 1, 2004in The Journal of Clinical Endocrinology and Metabolism5.61
Abhimanyu Garg63
Estimated H-index: 63
(UTSW: University of Texas Southwestern Medical Center)
It is well recognized that persons with generalized obesity suffer from a high risk of insulin resistance and its metabolic complications, such as type 2 diabetes mellitus, hypertriglyceridemia, low levels of high density lipoprotein cholesterol, hypertension, hepatic steatosis, hyperuricemia, and atherosclerotic vascular disease (1–3). However, whether accumulation of adipose tissue in a particular anatomical compartment (regional adiposity) confers an excess risk of insulin resistance and its ...
Published on Aug 1, 2004in International Journal of Obesity4.51
Altan Onat42
Estimated H-index: 42
Günsel Ş. Avcı3
Estimated H-index: 3
+ 3 AuthorsVedat Sansoy23
Estimated H-index: 23
Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk
Published on Jun 1, 2004in Journal of Clinical Investigation12.28
Søren Nielsen55
Estimated H-index: 55
(Mayo Clinic),
Zeng Kui Guo1
Estimated H-index: 1
+ 2 AuthorsMichael Dennis Jensen68
Estimated H-index: 68
Elevated FFA concentrations have been shown to reproduce some of the metabolic abnormalities of obesity. It has been hypothesized that visceral adipose tissue lipolysis releases excess FFAs into the portal vein, exposing the liver to higher FFA concentrations. We used isotope dilution/hepatic vein catheterization techniques to examine whether intra-abdominal fat contributes a greater portion of hepatic FFA delivery in visceral obesity. Obese women (n = 24) and men (n = 20) with a range of obesit...
Published on May 1, 2004in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
Isabelle Lemieux45
Estimated H-index: 45
Jean Vague from the University of Marseille was the first to foresee the importance of regional adipose tissue distribution when he suggested that a “male” pattern of body fat distribution, which he referred to as android obesity, was the form of obesity more likely to be accompanied by diabetes, hypertension, and heart disease, as opposed to the typical, rather benign, “female” pattern of body fatness, which he described as gynoid obesity.1 In the early 80’s, the late Per Bjorntorp from the Uni...
Published on Mar 1, 2004in Biochemical and Biophysical Research Communications2.71
Hiroyuki Motoshima7
Estimated H-index: 7
(Thomas Jefferson University),
Xiangdong Wu16
Estimated H-index: 16
(Thomas Jefferson University)
+ 1 AuthorsBarry J. Goldstein53
Estimated H-index: 53
(Thomas Jefferson University)
Abstract Adiponectin (also known as 30-kDa adipocyte complement-related protein or Acrp30) is an abundant adipocyte-derived plasma protein with anti-atherosclerotic and insulin-sensitizing properties. In order to investigate the potential mechanism(s) of the vascular protective effect of adiponectin, we used cultured bovine endothelial cells (BAECs) to study the effect of recombinant globular adiponectin (gAd) on cellular proliferation and the generation of reactive oxygen species (ROS) induced ...
Cited By464
Published on Dec 1, 2019in BMC Public Health2.57
Tsung-Lin Chiang (CCU: Chinese Culture University), Chu Chen (NTNU: National Taiwan Normal University)+ 2 AuthorsHuey-June Wu (CCU: Chinese Culture University)
To investigate the differences in body composition and metabolic syndrome (MS) under a daily 12,000-step strategy with or without moderate-intensity walking exercise in college students with obesity. Thirty-two adults with obesity (mean (s.d.) age: 19.72 (0.80) years; height: 165.38 (3.99) cm; wt: 83.31 (4.66) kg; body mass index: 30.38 (0.83) kg m− 2) were recruited and randomly assigned to the walking step goal group (WSG; achieving 12,000 steps per day), walking exercise group (WEG; achieving...
Published on Jul 1, 2019in Journal of the Neurological Sciences2.65
Ki-Woong Nam3
Estimated H-index: 3
(Seoul National University Hospital),
Hyuktae Kwon12
Estimated H-index: 12
(Seoul National University Hospital)
+ 6 AuthorsSeung Sik Hwang6
Estimated H-index: 6
(SNU: Seoul National University)
Abstract Although obesity has been proven as a risk factor of metabolic and cardiovascular diseases, there have been few studies addressing the association between obesity and cerebral white matter hyperintensity (WMH) volume with controversial findings. In this study, we evaluated the relationship between abdominal fat distribution and WMH volume in a neurologically healthy population. We performed an observational study in a consecutive series of subjects who were examined during voluntary hea...
James L. Rosenzweig11
Estimated H-index: 11
George L. Bakris102
Estimated H-index: 102
(U of C: University of Chicago)
+ 5 AuthorsB. Vergès38
Estimated H-index: 38
María Morales-Suárez-Varela31
Estimated H-index: 31
(University of Valencia),
Isabel Peraita-Costa (University of Valencia)+ 2 AuthorsAgustín Llopis-González12
Estimated H-index: 12
(University of Valencia)
The objective was to assess if there was any relationship between the amount of skeletal muscle mass (SMM) in children aged 6–8 years and their nutritional intake. The Valencian Anthropometry and C...
Published on Jul 15, 2019in Annals of Human Biology1.59
Ying-xiu Zhang9
Estimated H-index: 9
(CDC: Centers for Disease Control and Prevention),
Shu-Rong Wang3
Estimated H-index: 3
(Gulf Coast Regional Blood Center)
AbstractBackground: Waist-to-height ratio (WHtR) is proposed as a valid measure of abdominal obesity and health risks in practice. The present study examined the profiles of weight status and blood...
Published on Jun 14, 2019in Physiological Genomics2.58
Ingeborg Mm Ganeff (LUMC: Leiden University Medical Center), Maxime M. Bos1
Estimated H-index: 1
(LUMC: Leiden University Medical Center)
+ 1 AuthorsRaymond Noordam15
Estimated H-index: 15
(LUMC: Leiden University Medical Center)
Obesity is a causal risk factor for the development of age-related disease conditions, which includes type 2 diabetes mellitus, cardiovascular disease, and dementia. In Genome-Wide Association stud...
Published on 2019in Clinical Nutrition6.40
Omar Yaxmehen Bello Chavolla3
Estimated H-index: 3
(UNAM: National Autonomous University of Mexico),
Neftali Eduardo Antonio-Villa (UNAM: National Autonomous University of Mexico)+ 7 AuthorsErnesto Roldan-Valadez1
Estimated H-index: 1
(MSMU: I.M. Sechenov First Moscow State Medical University)
Abstract Background & Aims Intra-abdominal and visceral fat (VAT) are risk factors for the development of cardio-metabolic comorbidities; however its clinical assessment is limited by technology and required expertise for its assessment. We aimed to develop a novel score (METS-VF) to estimate VAT by combining the non-insulin-based METS-IR index, waist-height ratio (WHtr), age and sex. Methods We developed METS-VF in a sample of 366 individuals with Dual X-ray absorciometry (DXA). METS-VF was mod...
Published on Mar 19, 2019in Obesity Surgery3.60
Nathalie Bakker3
Estimated H-index: 3
Rick S. van den Helder + 4 AuthorsAlexander P. J. Houdijk24
Estimated H-index: 24
Purpose Weight loss before bariatric surgery with a low-calorie diet (LCD) has several advantages, including reduction of liver volume and an improved access to the lesser sac. Disadvantages include performing surgery in a state of undernutrition, side effects, costs and patient compliance. Omega-3 fatty acids may serve as an alternative to reduce liver steatosis.
Published on Jun 11, 2019in European Radiology3.96
Ebba Beller3
Estimated H-index: 3
Roberto Lorbeer20
Estimated H-index: 20
(LMU: Ludwig Maximilian University of Munich)
+ 8 AuthorsBirgit Ertl-Wagner28
Estimated H-index: 28
(LMU: Ludwig Maximilian University of Munich)
Objectives Prior studies relating body mass index (BMI) to brain volumes suggest an overall inverse association. However, BMI might not be an ideal marker, as it disregards different fat compartments, which carry different metabolic risks. Therefore, we analyzed MR-based fat depots and their association with gray matter (GM) volumes of brain structures, which show volumetric changes in neurodegenerative diseases.
Published on May 1, 2019in Nutrition3.59
Maria Pilar Aparisi Gómez3
Estimated H-index: 3
(Auckland City Hospital),
Federico Ponti9
Estimated H-index: 9
+ 6 AuthorsAlberto Bazzocchi17
Estimated H-index: 17
Abstract Objective The aim of this study was to review the existence and types of correlations between body composition densitometric parameters and laboratory values associated to cardiometabolic risk. Methods We retrospectively analyzed data from 316 individuals in the weight range from normality to super-obesity, submitted to total body dual-energy x-ray absorptiometry (DXA) scans and routine biochemistry at S.Orsola-Malpighi Hospital from June 2010 to March 2014. The study included 182 women...
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