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Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women

Published on Apr 11, 2005in JAMA Internal Medicine 20.77
· DOI :10.1001/archinte.165.7.777
Bret H. Goodpaster80
Estimated H-index: 80
(University of Pittsburgh),
Shanthi Krishnaswami6
Estimated H-index: 6
(University of Pittsburgh)
+ 6 AuthorsA. B. Newman140
Estimated H-index: 140
(University of Pittsburgh)
Cite
Abstract
Background:Themetabolicsyndromeisadisorderthat includes dyslipidemia, insulin resistance, and hypertension and is associated with an increased risk of diabetes andcardiovasculardisease.Wedeterminedwhetherpatterns of regional fat deposition are associated with metabolic syndrome in older adults. Methods: A cross-sectional study was performed that included a random, population-based, volunteer sample of Medicare-eligible adults within the general communities of Pittsburgh, Pa, and Memphis, Tenn. The subjects consisted of 3035 men and women aged 70 to 79 years, of whom 41.7% were black. Metabolic syndrome was defined by Adult Treatment Panel III criteria, including serum triglyceride level, high-density lipoprotein cholesterol level, glucose level, blood pressure, and waist circumference. Visceral, subcutaneous abdominal, intermuscular, and subcutaneous thigh adipose tissue was measured by computed tomography. Results:Visceral adipose tissue was associated with the metabolic syndrome in men who were of normal weight (odds ratio, 95% confidence interval: 2.1, 1.6-2.9), overweight (1.8, 1.5-2.1), and obese (1.2, 1.0-1.5), and in women who were of normal weight (3.3, 2.4-4.6), overweight (2.4, 2.0-3.0), and obese (1.7, 1.4-2.1), adjustingforrace.Subcutaneousabdominaladiposetissuewas associated with the metabolic syndrome only in normalweight men (1.3, 1.1-1.7). Intermuscular adipose tissue was associated with the metabolic syndrome in normalweight (2.3, 1.6-3.5) and overweight (1.2, 1.1-1.4) men. In contrast, subcutaneous thigh adipose tissue was inversely associated with the metabolic syndrome in obese men (0.9, 0.8-1.0) and women (0.9, 0.9-1.0). Conclusion: In addition to general obesity, the distribution of body fat is independently associated with the metabolic syndrome in older men and women, particularly among those of normal body weight. Arch Intern Med. 2005;165:777-783
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  • Citations (444)
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References37
Newest
Published on Jan 24, 2006in Annals of the New York Academy of Sciences 4.29
Eric Ravussin16
Estimated H-index: 16
(Pennington Biomedical Research Center),
Steven R. Smith71
Estimated H-index: 71
(Pennington Biomedical Research Center)
Abstract: It is widely accepted that increasing adiposity is associated with insulin resistance and increased risk of type 2 diabetes. The predominant paradigm used to explain this link is the portal/visceral hypothesis. This hypothesis proposes that increased adiposity, particularly in the visceral depots, leads to increased free fatty acid flux and inhibition of insulin action via Randle's effect in insulin-sensitive tissues. Recent data do not entirely support this hypothesis. As such, two ne...
Published on Apr 1, 2004in Journal of the American Geriatrics Society 4.11
Jennifer S. Brach44
Estimated H-index: 44
(UCSF: University of California, San Francisco),
Eleanor Marie Simonsick89
Estimated H-index: 89
(UCSF: University of California, San Francisco)
+ 2 AuthorsA. B. Newman140
Estimated H-index: 140
(UCSF: University of California, San Francisco)
OBJECTIVES: To determine whether older adults who exercise demonstrate higher levels of physical function than those who do not exercise but are physically active throughout the day. DESIGN: Cross-sectional examination of baseline data from the Health, Aging and Body Composition (Health ABC) study. SETTING: Health ABC field centers in Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand seventy-five well-functioning black and white men and women aged 70 to 79. MEASUREME...
Published on Apr 1, 2004in Nature Medicine 30.64
Apoorva Mandavilli7
Estimated H-index: 7
,
David Cyranoski31
Estimated H-index: 31
All the world loves to mock obese Americans, but weightier issues lurk in Asia, where diabetes and heart disease run rampant. The first hurdle may be a Western measure that is blind to the expanding fat in Asians' deceptively thin bodies.
Published on Aug 1, 2003in Medicine and Science in Sports and Exercise 4.48
Timo A. Lakka78
Estimated H-index: 78
,
David E. Laaksonen54
Estimated H-index: 54
+ 4 AuthorsJukka T. Salonen15
Estimated H-index: 15
ABSTRACTLAKKA, T. A., D. E. LAAKSONEN, H.-M. LAKKA, N. MANNIKKO, L. K. NISKANEN, R. RAURAMAA, and J. T. SALONEN. Sedentary Lifestyle, Poor Cardiorespiratory Fitness, and the Metabolic Syndrome. Med. Sci. Sports Exerc., Vol. 35, No. 8, pp. 1279–1286, 2003.PurposeThe cross-sectional associations of le
Published on Feb 1, 2003in Diabetes Care 15.27
Bret H. Goodpaster80
Estimated H-index: 80
,
Shanthi Krishnaswami6
Estimated H-index: 6
+ 6 AuthorsA. B. Newman140
Estimated H-index: 140
OBJECTIVE —We examined whether regional adipose tissue distribution, specifically that of skeletal muscle fat and visceral abdominal fat aggregation, is characteristic of elderly individuals with hyperinsulinemia, type 2 diabetes, and impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS —A total of 2,964 elderly men and women (mean age 73.6 years) were recruited for cross-sectional comparisons of diabetes or glucose tolerance, generalized obesity with dual-energy X-ray absorptiometry, a...
Published on Dec 27, 2002in Journal of Biological Chemistry
Chunli Yu7
Estimated H-index: 7
(Garvan Institute of Medical Research),
Yan Chen9
Estimated H-index: 9
(Garvan Institute of Medical Research)
+ 11 AuthorsGregory J. Cooney53
Estimated H-index: 53
(Garvan Institute of Medical Research)
Abstract Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine the mechanism by which fatty acids mediate this effect, rats were infused with either a lipid emulsion (consisting mostly of 18:2 fatty acids) or glycerol. Intracellular C18:2 CoA increased in a time-dependent fashion, reaching an ∼6-fold elevation by 5 h, wh...
Published on Oct 1, 2002in Diabetes 7.20
Ilan Gabriely22
Estimated H-index: 22
(Yeshiva University),
Xiao Hui Ma9
Estimated H-index: 9
(Yeshiva University)
+ 6 AuthorsNir Barzilai69
Estimated H-index: 69
(Yeshiva University)
Age-dependent changes in insulin action and body fat distribution are risk factors for the development of type 2 diabetes. To examine whether the accumulation of visceral fat (VF) could play a direct role in the pathophysiology of insulin resistance and type 2 diabetes, we monitored insulin action, glucose tolerance, and the expression of adipo-derived peptides after surgical removal of VF in aging (20-month-old) F344/Brown Norway (FBN) and in Zucker Diabetic Fatty (ZDF) rats. As expected, perip...
R. E. Van Pelt7
Estimated H-index: 7
(Anschutz Medical Campus),
Ellen M. Evans34
Estimated H-index: 34
+ 2 AuthorsWendy M. Kohrt60
Estimated H-index: 60
(Anschutz Medical Campus)
The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia were assessed: 1) area under the curve for the insulin (INSAUC) response to an oral glucose toleran...
Published on Feb 21, 2002in The New England Journal of Medicine 70.67
Elif Arioglu Oral6
Estimated H-index: 6
(NIH: National Institutes of Health),
Vinaya Simha20
Estimated H-index: 20
(University of Texas at Austin)
+ 9 AuthorsSimeon I. Taylor59
Estimated H-index: 59
(NIH: National Institutes of Health)
Background The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition. Methods Nine female patients (age range, 15 to 42 years; eight with diabetes mellitus) who had lipodystrophy and serum leptin levels of less than 4 ng per milliliter (0.32 nmol per milliliter) received recombina...
Published on Jan 16, 2002in JAMA 51.27
Earl S. Ford110
Estimated H-index: 110
(AMA: American Medical Association),
Wayne H. Giles79
Estimated H-index: 79
(AMA: American Medical Association),
William H. Dietz97
Estimated H-index: 97
(CDC: Centers for Disease Control and Prevention)
ContextThe Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III) highlights the importance of treating patients with the metabolic syndrome to prevent cardiovascular disease. Limited information is available about the prevalence of the metabolic syndrome in the United States, however.ObjectiveTo estimate the prevalence of the metabolic syndrome in the United States as defined by the ATP III re...
Cited By444
Newest
Published on Mar 13, 2019in Surgical and Radiologic Anatomy 1.04
A. Djuric-Stefanovic7
Estimated H-index: 7
(University of Belgrade),
N. Gordanic + 3 AuthorsS. Knezevic (University of Belgrade)
Purpose To explore individual variations in visibility of the fat planes between the pancreatic parenchyma and adjacent organs and blood vessels using the multi-detector-computed tomography (MDCT).
Published on Nov 1, 2018in Neurochemistry International 3.99
Olivia J. Gannon3
Estimated H-index: 3
(Albany Medical College),
Lisa S. Robison6
Estimated H-index: 6
(Albany Medical College)
+ 1 AuthorsKristen L. Zuloaga11
Estimated H-index: 11
(Albany Medical College)
Abstract Vascular contributions to cognitive impairment and dementia (VCID) is the second most common cause of dementia. While males overall appear to be at a slightly higher risk for VCID throughout most of the lifespan (up to age 85), some risk factors for VCID more adversely affect women. These include female-specific risk factors associated with pregnancy related disorders (e.g. preeclampsia), menopause, and poorly timed hormone replacement. Further, presence of certain co-morbid risk factor...
Published on May 1, 2019in Diabetes Research and Clinical Practice 3.24
Shih-Ming Chuang , Hong-Mou Shih + 3 AuthorsChun-Chuan Lee1
Estimated H-index: 1
Abstract Background While metabolic syndrome can independently predict the development of diabetic kidney disease (DKD) in patients with type 2 diabetes, the risk factors for DKD progression have rarely been discussed. The purpose of this study is to evaluate the association between metabolic syndrome and the progression of DKD in patients with type 2 diabetes. Material and methods This retrospective observational cohort study lasted approximately five years. We defined metabolic syndrome using ...
Laura A. Schaap18
Estimated H-index: 18
(PHRI: Public Health Research Institute)
Stephan Sachs4
Estimated H-index: 4
,
Simona Zarini22
Estimated H-index: 22
(Anschutz Medical Campus)
+ 14 AuthorsAnna Kerege10
Estimated H-index: 10
(Anschutz Medical Campus)
Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in humans to test f...
Published on Apr 26, 2019in Frontiers in Physiology 3.20
Ayoub Saeidi2
Estimated H-index: 2
(University of Mazandaran),
Georges Jabbour1
Estimated H-index: 1
(Qatar University)
+ 7 AuthorsHassane Zouhal19
Estimated H-index: 19
(University of Rennes)
We examined the effects of the independent and combined effects of Zataria multiflora supplementation and circuit resistance training (CRT) on selected adipokines among postmenopausal women. Forty-eight postmenopausal women were divided into 4 groups: Exercise (EG, n =12), Zataria multiflora (ZMG, n =12), exercise and Zataria multiflora (ZMEG, n =12), and control (CG, n=12). Participants in experimental groups either performed CRT (3 sessions per week with intensity at 55% of one-repetition maxi...
Published on Apr 9, 2019in PLOS ONE 2.78
Yuan-Yuei Chen3
Estimated H-index: 3
,
Wen-Hui Fang6
Estimated H-index: 6
+ 6 AuthorsWei-Liang Chen9
Estimated H-index: 9
Published on Apr 1, 2019in Journal of Clinical Densitometry 2.18
Brett S. Nickerson4
Estimated H-index: 4
,
Brett S. Nickerson1
Estimated H-index: 1
(TAMIU: Texas A&M International University)
+ 1 AuthorsBrian Kliszczewicz5
Estimated H-index: 5
Abstract This study examined the agreement between 2 segmental bioimpedance analysis (BIA) devices, air displacement plethysmography (BOD POD), and dual energy X-ray absorptiometry (DXA) for estimating body composition in obese adults. Fifty obese adults (25 men and 25 women; age = 34.20 ± 11.19 years; BMI = 36.14 ± 5.33 kg/m 2 ) had their body fat percentage (BF%) and fat-free mass (FFM) evaluated with 2 segmental BIA devices (InBody 230 and InBody 720), BOD POD, and DXA (Lunar iDXA). Body comp...
Published on Mar 14, 2019in Comprehensive Physiology 6.25
Gabriel B. Bernasochi3
Estimated H-index: 3
,
Jimmy D. Bell69
Estimated H-index: 69
+ 2 AuthorsWah Chin Boon25
Estimated H-index: 25