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Abstract
Background:Themetabolicsyndromeisadisorderthat includes dyslipidemia, insulin resistance, and hypertension and is associated with an increased risk of diabetes andcardiovasculardisease.Wedeterminedwhetherpatterns of regional fat deposition are associated with metabolic syndrome in older adults. Methods: A cross-sectional study was performed that included a random, population-based, volunteer sample of Medicare-eligible adults within the general communities of Pittsburgh, Pa, and Memphis, Tenn. The subjects consisted of 3035 men and women aged 70 to 79 years, of whom 41.7% were black. Metabolic syndrome was defined by Adult Treatment Panel III criteria, including serum triglyceride level, high-density lipoprotein cholesterol level, glucose level, blood pressure, and waist circumference. Visceral, subcutaneous abdominal, intermuscular, and subcutaneous thigh adipose tissue was measured by computed tomography. Results:Visceral adipose tissue was associated with the metabolic syndrome in men who were of normal weight (odds ratio, 95% confidence interval: 2.1, 1.6-2.9), overweight (1.8, 1.5-2.1), and obese (1.2, 1.0-1.5), and in women who were of normal weight (3.3, 2.4-4.6), overweight (2.4, 2.0-3.0), and obese (1.7, 1.4-2.1), adjustingforrace.Subcutaneousabdominaladiposetissuewas associated with the metabolic syndrome only in normalweight men (1.3, 1.1-1.7). Intermuscular adipose tissue was associated with the metabolic syndrome in normalweight (2.3, 1.6-3.5) and overweight (1.2, 1.1-1.4) men. In contrast, subcutaneous thigh adipose tissue was inversely associated with the metabolic syndrome in obese men (0.9, 0.8-1.0) and women (0.9, 0.9-1.0). Conclusion: In addition to general obesity, the distribution of body fat is independently associated with the metabolic syndrome in older men and women, particularly among those of normal body weight. Arch Intern Med. 2005;165:777-783
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"The Association Between Physical Function and Lifestyle Activity and Exercise in the Health, Aging and Body Composition Study"
Jennifer S. Brach49
Estimated H-index: 49
("University of California, San Francisco"),
Eleanor M. Simonsick81
Estimated H-index: 81
("University of California, San Francisco"),
Stephen B. Kritchevsky68
Estimated H-index: 68
("University of California, San Francisco")
... (2 others)
OBJECTIVES: To determine whether older adults who exercise demonstrate higher levels of physical function than those who do not exercise but are physically active throughout the day. DESIGN: Cross-sectional examination of baseline data from the Health, Aging and Body Composition (Health ABC) study. SETTING: Health ABC field centers in Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS:...
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Central Role of the Adipocyte in the Metabolic Syndrome
Richard N. Bergman95
Estimated H-index: 95
(University of Southern California),
Gregg W. Van Citters9
Estimated H-index: 9
(University of Southern California),
Steven D. Mittelman28
Estimated H-index: 28
(University of Southern California)
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Abstract Insulin resistance is associated with a plethora of chronic illnesses, including Type 2 diabetes, dyslipidemia, clotting dysfunction, and colon cancer. The relationship between obesity and insulin resistance is well established, and an increase in obesity in Western countries is implicated in increased incidence of diabetes and other diseases. Central, or visceral, adiposity has been part...
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Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
2001 in Diabetes Care [IF: 11.86]
Bo Isomaa49
Estimated H-index: 49
(Lund University),
Peter Almgren64
Estimated H-index: 64
(Lund University),
Tiinamaija Tuomi70
Estimated H-index: 70
(Helsinki University Central Hospital)
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OBJECTIVE —To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WHO). RESEARCH DESIGN AND METHODS —A total of 4,483 subjects aged 35–70 years participating in a large family study of type 2 diabetes in Finland and Sweden (the Botnia study) were included in the analysis of cardiovascular ...
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News Feature: Asia's big problem
2004 in Nature Medicine [IF: 29.89]
Apoorva Mandavilli8
Estimated H-index: 8
,
David Cyranoski11
Estimated H-index: 11
All the world loves to mock obese Americans, but weightier issues lurk in Asia, where diabetes and heart disease run rampant. The first hurdle may be a Western measure that is blind to the expanding fat in Asians' deceptively thin bodies.
Cited 37 Source Cite this paper Add Collection
Contributions of total and regional fat mass to risk for cardiovascular disease in older women
R. E. Van Pelt6
Estimated H-index: 6
(Anschutz Medical Campus),
Ellen M. Evans31
Estimated H-index: 31
(University of Georgia),
Kenneth B. Schechtman68
Estimated H-index: 68
(Washington University in St. Louis)
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The aim of this study was to determine whether trunk fat mass, measured by dual-energy X-ray absorptiometry (DEXA), is predictive of insulin resistance and dyslipidemia, independently of arm and leg fat mass, in postmenopausal women. Total and regional body composition was measured by DEXA in 166 healthy, postmenopausal women (66 ± 4 yr). Four primary markers of insulin resistance and dyslipidemia...
Cited 199 Source Cite this paper Add Collection
"Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome"
Timo A. Lakka73
Estimated H-index: 73
(University of Eastern Finland),
David E. Laaksonen57
Estimated H-index: 57
(University of Eastern Finland),
Hanna-Maaria Lakka29
Estimated H-index: 29
(Pennington Biomedical Research Center)
... (4 others)
ABSTRACT LAKKA, T. A., D. E. LAAKSONEN, H.-M. LAKKA, N. MANNIKKO, L. K. NISKANEN, R. RAURAMAA, and J. T. SALONEN. Sedentary Lifestyle, Poor Cardiorespiratory Fitness, and the Metabolic Syndrome. Med. Sci. Sports Exerc., Vol. 35, No. 8, pp. 1279–1286, 2003. The cross-sectional associations of leisure-time physical activity (LTPA) and cardiorespiratory fitness with the metabolic syndrome (MS) were i...
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Role of Deep Abdominal Fat in the Association Between Regional Adipose Tissue Distribution and Glucose Tolerance in Obese Women
1989 in Diabetes [IF: 8.68]
Jean-Pierre Després67
Estimated H-index: 67
(Laval University),
André Nadeau50
Estimated H-index: 50
(Laval University),
Angelo Tremblay57
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(Laval University)
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Computed tomography (CT) was used to study the association between adipose tissue localization and glucose tolerance in a sample of 52 premenopausal obese women aged 35.7 ± 5.5 yr (mean ± SD) and with a body fat of 45.9 ± 5.5%. Body-fat mass and the body mass index (BMI) were significantly correlated with plasma glucose, insulin, and connecting peptide (C-peptide) areas after glucose (75 g) ingest...
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Insulin Resistance in Aging Is Related to Abdominal Obesity
1993 in Diabetes [IF: 8.68]
Wendy M. Kohrt30
Estimated H-index: 30
(Washington University in St. Louis),
J. P. Kirwan7
Estimated H-index: 7
(Washington University in St. Louis),
Myrlene A Staten1
Estimated H-index: 1
(Washington University in St. Louis)
... (3 others)
Studies have shown that insulin resistance increases with age, independent of changes in total adiposity. However, there is growing evidence that the development of insulin resistance may be more closely related to abdominal adiposity. To evaluate the independent effects of aging and regional and total adiposity on insulin resistance, we performed hyperinsulinemic euglycemic clamps on 17 young (21...
Cited 239 Download Pdf Cite this paper Add Collection
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Susan K. Fried53
Estimated H-index: 53
(Rutgers University),
Dove A. Bunkin1
Estimated H-index: 1
,
Andrew S. Greenberg77
Estimated H-index: 77
(University of Miami)
The purpose of this study was to determine whether human adipocytes from different depots of obese subjects produce interleukin-6 (IL-6) and whether IL-6 release is regulated by glucocorticoids. Fragments of omental and abdominal sc adipose tissue released immunodetectable IL-6 into the medium during acute incubations. Omental adipose tissue released 2–3 times more IL-6 than did sc adipose tissue....
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Cited by424
Abdominal fat and risk of coronary heart disease in patients with peripheral arterial disease.
2007 in Obesity [IF: 3.87]
B.G. Brouwer5
Estimated H-index: 5
(Utrecht University),
Frank L.J. Visseren32
Estimated H-index: 32
(Utrecht University),
Ronald P. Stolk43
Estimated H-index: 43
(University Medical Center Groningen)
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Objective: We investigated whether the presence of concomitant coronary heart disease (CHD) in patients with peripheral arterial disease (PAD) can be explained by intra-abdominal fat accumulation and compared different measures of adiposity as predictors of CHD in patients with PAD. Research Methods and Procedures: Data were collected from patients enrolled in the Second Manifestations of ARTerial...
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Adverse prognosis associated with the metabolic syndrome in established coronary artery disease: Data from the EUROPA trial
2007 in Heart [IF: 6.06]
Caroline Daly17
Estimated H-index: 17
(Grupo México),
Per Hildebrandt45
Estimated H-index: 45
(Frederiksberg Hospital),
Michel E. Bertrand63
Estimated H-index: 63
(university of lille)
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Objective: To assess the prevalence of metabolic syndrome, and its effect on cardiovascular morbidity and mortality in patients with established coronary disease and to explore the inter-relationships between metabolic syndrome, diabetes, obesity and cardiovascular risk. Methods: The presence of metabolic syndrome was determined in 8397 patients with stable coronary disease from the European Trial...
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Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study: Eight-Year Changes in Body Composition in Look AHEAD
2015 in Obesity [IF: 3.87]
Henry J. Pownall42
Estimated H-index: 42
(Baylor College of Medicine),
George A. Bray65
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Lynne E. Wagenknecht66
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(Wake Forest University)
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Metabolic Health Status and the Obesity Paradox in Older Adults
Feon W. Cheng3
Estimated H-index: 3
(Pennsylvania State University),
Xiang Gao39
Estimated H-index: 39
(Pennsylvania State University),
Diane C. Mitchell42
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(Pennsylvania State University)
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ABSTRACTThe explanation for reduced mortality among older persons with overweight or class I obesity compared to those of desirable weight remains unclear. Our objective was to investigate the joint effects of body mass index (BMI) and metabolic health status on all-cause mortality in a cohort of advanced age. Adults aged 74 ± 4.7 (mean ± SD) years at baseline (n = 4551) were categorized according...
Cited 6 Source Cite this paper Add Collection
Metabolic and endocrine disturbances in psychiatric disorders: a multidisciplinary approach to appropriate atypical antipsychotic utilization.
2005 in Cns Spectrums [IF: 3.59]
Prakash S. Masand1
Estimated H-index: 1
(Boston University),
Larry Culpepper1
Estimated H-index: 1
(Harvard University),
David C. Henderson35
Estimated H-index: 35
(Loma Linda University)
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Patients with psychiatric disorders have an increased rate of cardiovascular morbidity and mortality compared with the general population. Metabolic issues such as weight gain, dyslipidemia, diabetes mellitus, diabetic ketoacidosis, and pancreatitis have been reported with the use of antipsychotic agents. Although atypical antipsychotics have not been linked directly to the development of metaboli...
Cited 29 Source Cite this paper Add Collection
"Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial."
Wenjie Ma3
Estimated H-index: 3
(Harvard University),
Tao Huang10
Estimated H-index: 10
(National University of Singapore),
Molin Wang30
Estimated H-index: 30
(Harvard University)
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Two-year changes in circulating adiponectin, ectopic fat distribution and body composition in response to weight-loss diets: the POUNDS Lost Trial
Cited 5 Source Cite this paper Add Collection
Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)Objective: To investigate the significance of intra-abdominal fat area (IAFA) on new onset of individual components of the metabolic syndrome: high blood pressure, dyslipidemia, or hyperglycemia. Methods: We conducted a longitudinal study using checkup data of a hospital from 1994 to 2010. Of 25,255 subjects, we examined 1,380 Japanese, who underwent computed tomography to measure IAFA and had no ...
Cited 23 Source Cite this paper Add Collection
Different ways to assess overweight and obesity related to metabolic syndromeINTRODUCTION: Obesity is a health problem related to diabetes mellitus and atherosclerosis events. Metabolic syndrome includes some of atherosclerosis risk factors and has a fat accumulation as one of its main physiopathologic mechanisms but its assessment changes among criteria used for its diagnosis. OBJECTIVE: Aim of this study was to define the contribution of different variations of overweigh...
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"Prevalence, Distribution, and Risk Factor Correlates of High Pericardial and Intrathoracic Fat Depots in the Framingham Heart Study"
George Thanassoulis27
Estimated H-index: 27
(Boston University),
Massaro Jm5
Estimated H-index: 5
(Boston University),
Udo Hoffmann58
Estimated H-index: 58
(Harvard University)
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Background— Pericardial and intrathoracic fat depots may represent novel risk factors for obesity-related cardiovascular disease. We sought to determine the prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat deposits. Methods and Results— Participants from the Framingham Heart Study (n=3312; mean age, 52 years; 48% women) underwent multidetector CT imagi...
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