Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase
Abstract
Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several glycolytic enzymes, phosphofructokinase (PFK) in particular, have shown promise as potential drug targets. Herein, we describe the discovery of ML251, a novel nanomolar inhibitor of T....
Paper Details
Title
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase
Published Date
Nov 8, 2013
Volume
5
Issue
1
Pages
12 - 17
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