Autophagy and neurodegeneration

Published on Jan 2, 2015in Journal of Clinical Investigation12.282
· DOI :10.1172/JCI73944
Rebecca A. Frake2
Estimated H-index: 2
Thomas Ricketts9
Estimated H-index: 9
+ 1 AuthorsDavid C. Rubinsztein115
Estimated H-index: 115
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.
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