Ending Propylthiouracil-Induced Liver Failure in Children

To the Editor: Graves' disease is treated with antithyroid drugs, radioactive iodine, or surgery.1,2 Propylthiouracil and methimazole are widely used in children as first-line therapy.1,2 Over the past 60 years of propylthiouracil and methimazole use, reports of propylthiouracil-related liver failure and death have accumulated.3–5 In contrast, this problem has not been reported with methimazole use in children.3,5 Several observations can be...