Structure-function relationships in methionine adenosyltransferases

Volume: 66, Issue: 4, Pages: 636 - 648
Published: Feb 1, 2009
Abstract
Methionine adenosyltransferases (MATs) are the family of enzymes that synthesize the main biological methyl donor, S-adenosylmethionine. The high sequence conservation among catalytic subunits from bacteria and eukarya preserves key residues that control activity and oligomerization, which is reflected in the protein structure. However, structural differences among complexes with substrates and products have led to proposals of several reaction...
Paper Details
Title
Structure-function relationships in methionine adenosyltransferases
Published Date
Feb 1, 2009
Volume
66
Issue
4
Pages
636 - 648
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