Oligomerization capacity of two arylsulfatase A mutants: C300F and P425T

Volume: 306, Issue: 1, Pages: 293 - 297
Published: Jun 1, 2003
Abstract
Arylsulfatase A (ARSA) is a lysosomal enzyme implicated in most cases of metachromatic leukodystrophy (MLD). The quaternary structure of ARSA is pH-dependent: at neutral pH, ARSA is a homodimeric protein; at lysosomal (acidic) pH, ARSA is homo-octameric. This dimer-octamer transition seems to be of major importance for the stability of the enzyme in the lysosomal milieu. Sedimentation analysis was used to study the oligomerization capacity of...
Paper Details
Title
Oligomerization capacity of two arylsulfatase A mutants: C300F and P425T
Published Date
Jun 1, 2003
Volume
306
Issue
1
Pages
293 - 297
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.