The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila
Abstract
Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was...
Paper Details
Title
The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila
Published Date
Apr 16, 2015
Journal
Volume
11
Issue
4
Pages
e1004692 - e1004692
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