Expression and Function of B7 Family Molecules on Blasts of Patients with Myelodysplastic Syndromes

Optimal activation of T cells requires second costimulatory signals together with the first signal delivered by engagement of the T‑cell receptor with the peptide‑MHC complex on antigen presenting cells (APCs such as macrophages B cells and dendritic cells. The interaction between B7 molecules i.e. B7‑1 (CD80B7‑2 (CD86 on APCs and CD28CTLA‑4 molecules on T cells is the most well‑characterized costimulatory signal pathway and is thought to be...