Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery
Volume: 7, Issue: 2, Pages: 210 - 219
Published: Apr 1, 2011
Abstract
The transfection efficiencies of 25-kDa branched polyethylenimine (B-PEI) and 22-kDa linear PEI (L-PEI) with both DNA and small interfering RNA (siRNA) were compared and correlated with their biophysical properties relating to complex formation, stability, and disassembly. L-PEI-DNA complexes transfected (5.18 × 10(8) relative luminescence units [RLU]/mg) around fivefold better than B-PEI-DNA complexes (0.95 × 10(8) RLU/mg), whereas B-PEI-siRNA...
Paper Details
Title
Comparative structural and functional studies of nanoparticle formulations for DNA and siRNA delivery
Published Date
Apr 1, 2011
Volume
7
Issue
2
Pages
210 - 219
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