New strategy for the diastereoselective synthesis of bicyclic “pre-activated” analogues of cyclophosphamide
Abstract
null null The diastereoselective synthesis of “pre-activated” analogues of cyclophosphamide in the 3-[bis(2-chloroethyl)amino]-2-aza-4,9-dioxa-3-phosphabicyclo(4.3.0)nonane 3-oxide series in described, using either the phosphorylation of an azidoalcohol followed by a reductive cyclisation or the phosphorylation of an acetal alcohol followed by an unprecedent direct Lewis acid catalyzed intramolecular...
Paper Details
Title
New strategy for the diastereoselective synthesis of bicyclic “pre-activated” analogues of cyclophosphamide
Published Date
Apr 16, 1998
Journal
Volume
39
Issue
16
Pages
2315 - 2318
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Notes
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