Passing the baton: the HIF switch
Abstract
Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription factors, HIF-1 and HIF-2, which have both overlapping and unique target genes. HIF target gene activation is highly context specific and is not a reliable indicator of which HIF-α isoform is active. For example, in some cell lines, the individual HIFs have specific...
Paper Details
Title
Passing the baton: the HIF switch
Published Date
Sep 1, 2012
Volume
37
Issue
9
Pages
364 - 372
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