Quantitative analysis of lentiviral transgene expression in mice over seven generations
Abstract
Lentiviral transgenesis is now recognized as an extremely efficient and cost-effective method to produce transgenic animals. Transgenes delivered by lentiviral vectors exhibited inheritable expression in many species including those which are refractory to genetic modification such as non-human primates. However, epigenetic modification was frequently observed in lentiviral integrants, and transgene expression found to be inversely correlated...
Paper Details
Title
Quantitative analysis of lentiviral transgene expression in mice over seven generations
Published Date
Jan 22, 2010
Journal
Volume
19
Issue
5
Pages
775 - 784
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Notes
History