Diphtheria toxin: a novel cytocidal enzyme
Abstract
Diphtheria toxin specifically catalyses inactivation of elongation factor-2causing inhibition of protein synthesis, so that uptake of a single molecule of toxin may kill any eukaryotic cell. Protein engineering of such powerful bacterial toxins could produce potent therapeutic agents, or inactive mutants for use in...
Paper Details
Title
Diphtheria toxin: a novel cytocidal enzyme
Published Date
Jan 1, 1987
Volume
12
Pages
28 - 31
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