Mechanisms for the Transport of α,ω-Dicarboxylates through the Mitochondrial Inner Membrane

α,ω-Dicarboxylates have antibacterial properties, have been used in the treatment of hyperpigmentary disorders, are active against various melanoma cell lines, and can also undergo β-oxidation. Little, however, is known about their transport. In this paper, we examine the mitochondrial transport of α,ω-dicarboxylates ranging from oxalate (DC2) to sebacate (DC10). DC2-DC10 are transported by the inner membrane anion channel (IMAC). DC6-DC10 are...