Membrane protein structural biology: the high throughput challenge
Abstract
Membrane proteins represent roughly one-third of the proteins encoded in the genome, yet fewer than 1% of the proteins are of known structure. High-throughput crystallography offers the hope of correcting this imbalance. In order for large-scale membrane protein structural biology to realize its full promise, however, significant technical challenges must be overcome, the two most substantial being facile protein overexpression and reliable...
Paper Details
Title
Membrane protein structural biology: the high throughput challenge
Published Date
Apr 1, 2003
Volume
142
Issue
1
Pages
144 - 153
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